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TOP3B antibody (Topoisomerase (DNA) III beta) (C-Term)

Details for Product anti-TOP3B Antibody No. ABIN955293, Supplier: Log in to see
Antigen
  • TOP3B1
Epitope
C-Term, AA 825-854
16
15
10
8
7
2
2
1
1
Reactivity
Human, Mouse (Murine)
49
9
3
Host
Rabbit
32
17
Clonality
Polyclonal
Conjugate
This TOP3B antibody is un-conjugated
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
45
34
3
2
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 825-854 amino acids from the C-terminal region of human TOP3B
Isotype Ig
Specificity This antibody detects TOP3B (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Protein A column followed by peptide affinity purification
Alternative Name TOP3B (TOP3B Antibody Abstract)
Background This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity, however, not all variants have been fully described.Synonyms: DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1, TOP3B1
Gene ID 8940
NCBI Accession NP_003926
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-TOP3B antibody (Topoisomerase (DNA) III beta) (C-Term) (ABIN955293) TOP3B Antibody (C-term) western blot analysis in mouse bladder tissue lysates (35 µg/...
Background publications Oliveira-Costa, Zanetti, Oliveira, Soares, Ramalho, Silva Ramalho, Garcia, Ribeiro-Silva: "Significance of topoisomerase IIIβ expression in breast ductal carcinomas: strong associations with disease-specific survival and metastasis." in: Human pathology, Vol. 41, Issue 11, pp. 1624-30, 2010 (PubMed).

Lesch, Timmesfeld, Renner, Halperin, Röser, Nguyen, Craig, Romanos, Heine, Meyer, Freitag, Warnke, Romanos, Schäfer, Walitza, Reif, Stephan, Jacob: "Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 115, Issue 11, pp. 1573-85, 2008 (PubMed).

Cho, Park, Han, Chung: "Identification of the functional elements in the promoter region of human DNA topoisomerase IIIbeta gene." in: Biochimica et biophysica acta, Vol. 1679, Issue 3, pp. 272-8, 2004 (PubMed).

Lehner, Sanderson: "A protein interaction framework for human mRNA degradation." in: Genome research, Vol. 14, Issue 7, pp. 1315-23, 2004 (PubMed).