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Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) (AA 1114-1142), (Middle Region) antibody

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AA 1114-1142, Middle Region
(14), (14), (14), (13), (10), (9), (9), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(67), (3), (3)
(60), (5), (2)
(5), (5), (5), (5), (5), (5)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(35), (34), (26), (8), (7), (5), (2), (1), (1)
Pubmed 5 references available
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Quantity 0.4 mL
Shipping to United States ( )
Immunogen KLH conjugated synthetic peptide between 1114-1142 amino acids from the Central region of Human TOPBP1
Isotype Ig
Specificity This antibody detects Human TOPBP1 (Center).
Purification Protein A column followed by peptide affinity purification
Alternative Name TOPBP1 (TOPBP1 Antibody Abstract)
Background TOPBP1 is a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.Synonyms: DNA topoisomerase 2-binding protein 1, DNA topoisomerase II-binding protein 1, DNA topoisomerase IIbeta-binding protein 1, KIAA0259
Molecular Weight 170679 Da
Gene ID 11073
NCBI Accession NP_008958
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Huo, Bai, Xu et al.: "Crystal structure of the N-terminal region of human Topoisomerase IIβ binding protein 1." in: Biochemical and biophysical research communications, Vol. 401, Issue 3, pp. 401-5, 2010 (PubMed).

Blackford, Patel, Forrester et al.: "Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 27, pp. 12251-6, 2010 (PubMed).

Takeishi, Ohashi, Ogawa et al.: "Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 15, Issue 7, pp. 761-71, 2010 (PubMed).

Gong, Kim, Leung et al.: "BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control." in: Molecular cell, Vol. 37, Issue 3, pp. 438-46, 2010 (PubMed).

Couch, Wang, Bamlet et al.: "Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 1, pp. 251-7, 2010 (PubMed).

Catalog No. ABIN955294

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