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Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) (AA 1114-1142), (Middle Region) antibody

Details for Product No. ABIN955294
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Antigen
Synonyms TOP2BP1, AI256758, mKIAA0259, 1110031N14Rik, 2810429C13Rik, D430026L04Rik, TopBP1-A, TopBP1-B, Xmus101, XtopBP, cut5, mus101, top2bp1, RGD1562949, TOPBP1, F2P24.3, F2P24_3, meiosis defective 1
Epitope
AA 1114-1142, Middle Region
(8), (8), (7), (6), (6), (6), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(34)
Host
Rabbit
(31), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3)
Application
ELISA, Western Blotting (WB)
(20), (17), (17), (5), (1), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN955294
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen KLH conjugated synthetic peptide between 1114-1142 amino acids from the Central region of Human TOPBP1
Specificity This antibody detects Human TOPBP1 (Center).
Purification Protein A column followed by peptide affinity purification
Alternative Name TOPBP1
Background TOPBP1 is a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
Alternate names: DNA topoisomerase 2-binding protein 1, DNA topoisomerase II-binding protein 1, DNA topoisomerase IIbeta-binding protein 1, KIAA0259
Molecular Weight 170679 Da
Gene ID 11073
NCBI Accession NP_008958
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Couch, Wang, Bamlet et al.: "Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 1, pp. 251-7, 2010 (PubMed).

Gong, Kim, Leung et al.: "BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control." in: Molecular cell, Vol. 37, Issue 3, pp. 438-46, 2010 (PubMed).

Takeishi, Ohashi, Ogawa et al.: "Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 15, Issue 7, pp. 761-71, 2010 (PubMed).

Blackford, Patel, Forrester et al.: "Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 27, pp. 12251-6, 2010 (PubMed).

Huo, Bai, Xu et al.: "Crystal structure of the N-terminal region of human Topoisomerase IIβ binding protein 1." in: Biochemical and biophysical research communications, Vol. 401, Issue 3, pp. 401-5, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN955294
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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