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Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4) (AA 811-840), (C-Term) antibody

Details for Product No. ABIN955338, Supplier: Log in to see
Antigen
  • TRPC5
  • TRPC4
  • HTRP-4
  • HTRP4
  • TRP4
  • CCE1
  • STRPC4
  • Trp4
  • Trrp4
Epitope
C-Term, AA 811-840
39
31
15
6
4
2
2
2
1
1
1
1
Reactivity
Human
76
74
42
4
4
3
2
Host
Rabbit
49
46
18
3
Clonality
Polyclonal
Conjugate
Un-conjugated
5
5
5
5
5
4
2
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
110
42
41
41
37
33
8
2
1
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 811-840 amino acids from the C-terminal region of human TRPC4
Isotype Ig
Specificity This antibody detects TRPC4 / TRP4 (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A column followed by peptide affinity purification
Alternative Name TRPC4 (TRPC4 Antibody Abstract)
Background Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.Synonyms: CCE1, Capacitative calcium entry channel 1, Short transient receptor potential channel 4, TRP-4, Trp-related protein 4
Gene ID 7223
NCBI Accession NP_001129427
Research Area Signaling, Tyrosine Kinases
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4) (AA 811-840), (C-Term) antibody (ABIN955338) TRPC4 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35 µg/la...
Background publications von Spiczak, Muhle, Helbig et al.: "Association study of TRPC4 as a candidate gene for generalized epilepsy with photosensitivity." in: Neuromolecular medicine, Vol. 12, Issue 3, pp. 292-9, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Mace, Lussier, Boulay et al.: "TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling." in: Journal of cellular physiology, Vol. 225, Issue 2, pp. 444-53, 2010 (PubMed).

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