Vacuolar Protein Sorting 45 Homolog (S. Cerevisiae) (VPS45) (C-Term), (AA 460-489) antibody

Details for Product No. ABIN955526
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Antigen
Synonyms
CG8228, DmVps45, Dmel\\CG8228, MENE (3R)-C, MENE(3R)-C, VPS45, Vps45p, dVps45, VPS45A, si:dkey-200h23.3, vps45, ATVPS45, T14N5.2, T14N5_2, vacuolar protein sorting 45, AI462172, AW554165, mVps45, H1,  ... show more
CG8228, DmVps45, Dmel\\CG8228, MENE (3R)-C, MENE(3R)-C, VPS45, Vps45p, dVps45, VPS45A, si:dkey-200h23.3, vps45, ATVPS45, T14N5.2, T14N5_2, vacuolar protein sorting 45, AI462172, AW554165, mVps45, H1, H1VPS45, SCN5, VPS45B, VPS54A, VSP45, VSP45A, Vsp45a show less
Epitope
C-Term, AA 460-489
(19), (7), (6), (2), (1), (1), (1)
Reactivity
Human
(32), (14), (9), (4), (2), (1)
Host
Rabbit
(25), (11), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(36), (20), (3), (2), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
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Catalog No. ABIN955526
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Immunogen KLH conjugated synthetic peptide between 460-489 amino acids from the C-terminal region of human VPS45
Isotype Ig
Specificity This antibody detects VPS45 (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A column followed by peptide affinity purification
Alternative Name VPS45
Background Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. [provided by RefSeq].Synonyms: VPS45A, VPS45B, Vacuolar protein sorting-associated protein 45
Gene ID 11311
NCBI Accession NP_009190
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Background publications Nielsen, Christoforidis, Uttenweiler-Joseph et al.: "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain." in: The Journal of cell biology, Vol. 151, Issue 3, pp. 601-12, 2000 (PubMed).

de Renzis, Sönnichsen, Zerial: "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes." in: Nature cell biology, Vol. 4, Issue 2, pp. 124-33, 2002 (PubMed).

Dulubova, Yamaguchi, Gao et al.: "How Tlg2p/syntaxin 16 'snares' Vps45." in: The EMBO journal, Vol. 21, Issue 14, pp. 3620-31, 2002 (PubMed).

Kim, Ueda, Kominami et al.: "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex." in: Biochemical and biophysical research communications, Vol. 311, Issue 3, pp. 577-82, 2003 (PubMed).

Rahajeng, Caplan, Naslavsky: "Common and distinct roles for the binding partners Rabenosyn-5 and Vps45 in the regulation of endocytic trafficking in mammalian cells." in: Experimental cell research, Vol. 316, Issue 5, pp. 859-74, 2010 (PubMed).

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