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WD Repeat Domain 12 (WDR12) (AA 209-239), (Middle Region) antibody

Details for Product No. ABIN955544, Supplier: Log in to see
Antigen
  • WDR12
  • YTM1
  • 4933402C23Rik
  • Ytm1
  • Ytm1p
  • fb24f09
  • wu:fb24f09
  • zgc:55609
Epitope
AA 209-239, Middle Region
28
17
15
3
2
1
1
1
Reactivity
Human
39
5
3
3
1
Host
Rabbit
40
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
4
4
4
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
37
29
14
2
Supplier
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Immunogen KLH conjugated synthetic peptide between 209-239 amino acids from the Central region of human WDR12
Isotype Ig
Specificity This antibody detects WDR12 (Center).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A column followed by peptide affinity purification
Alternative Name WDR12 (WDR12 Antibody Abstract)
Background This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.Synonyms: Ribosome biogenesis protein WDR12, WD repeat-containing protein 12
Gene ID 55759
NCBI Accession NP_060726
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-WD Repeat Domain 12 (WDR12) (AA 209-239), (Middle Region) antibody (ABIN955544) WDR12 Antibody (Center) western blot analysis in HepG2 cell line lysates (35 µg/lane)...
Background publications , Kathiresan, Voight et al.: "Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants." in: Nature genetics, Vol. 41, Issue 3, pp. 334-41, 2009 (PubMed).

Rohrmoser, Hölzel, Grimm et al.: "Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit." in: Molecular and cellular biology, Vol. 27, Issue 10, pp. 3682-94, 2007 (PubMed).

Higa, Wu, Ye et al.: "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation." in: Nature cell biology, Vol. 8, Issue 11, pp. 1277-83, 2006 (PubMed).