WAP Four-Disulfide Core Domain 1 (WFDC1) (C-Term), (AA 147-177), (His163) antibody

Details for Product No. ABIN955571
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Synonyms WFDC1, zgc:158671, PS20, 2310058A03Rik, ps20
C-Term, AA 147-177, His163
(26), (14), (12), (3), (2), (2)
(37), (13), (4)
(26), (23)
(4), (4), (4), (4), (4), (4)
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(37), (35), (16), (15), (3), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN955571
357.50 $
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Immunogen KLH conjugated synthetic peptide between 147-177 (H163)amino acids from the C-terminal region of human WFDC1
Isotype Ig
Specificity This antibody detects PS20 (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A column followed by peptide affinity purification
Alternative Name WFDC1 / PS20
Background This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81 % amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene.Synonyms: Prostate stromal protein ps20, WAP four-disulfide core domain protein 1, ps20 growth inhibitor
Gene ID 58189
NCBI Accession NP_067020
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Background publications Briggs, Ramsay, Madden et al.: "Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis." in: Genes and immunity, Vol. 11, Issue 3, pp. 199-208, 2010 (PubMed).

Liu, Howell, Ren et al.: "Expression and functional analysis of the WAP four disulfide core domain 1 gene in human melanoma." in: Clinical & experimental metastasis, Vol. 26, Issue 7, pp. 739-49, 2009 (PubMed).

Madar, Brosh, Buganim et al.: "Modulated expression of WFDC1 during carcinogenesis and cellular senescence." in: Carcinogenesis, Vol. 30, Issue 1, pp. 20-7, 2009 (PubMed).

Alvarez, Reading, King et al.: "WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-permissive CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection." in: Journal of virology, Vol. 82, Issue 1, pp. 471-86, 2007 (PubMed).

Watson, Kamkar, James et al.: "Molecular analysis of WFDC1/ps20 gene in prostate cancer." in: The Prostate, Vol. 61, Issue 2, pp. 192-9, 2004 (PubMed).

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