YTHDF2 antibody (C-Term)

Catalog No. ABIN955619

Product Details anti-YTHDF2 Antibody

Target: YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))

Binding Specificity: AA 550-579, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YTHDF2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects YTHDF2 (C-term).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 550-579 amino acids from the C-terminal region of human YTHD2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Target Details for YTHDF2

Target: YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))

Alternative Name: YTHDF2 (YTHDF2 Products)

Synonyms: MGC82537 antibody, HGRG8 antibody, NY-REN-2 antibody, YTH N(6)-methyladenosine RNA binding protein 2 L homeolog antibody, YTH N6-methyladenosine RNA binding protein 2 antibody, ythdf2.L antibody, YTHDF2 antibody

Background: YTHDF2 is a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosme 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene.Synonyms: CLL-associated antigen KW-14, HGRG8, High-glucose-regulated protein 8, KW-14, NY-REN-2, Renal carcinoma antigen NY-REN-2, YTH domain family protein 2

Gene ID: 51441

NCBI Accession: NP_001166299