MANF antibody

Catalog No. ABIN956418

Product Details anti-MANF Antibody

Target: MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MANF antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Human MANF

Purification: IgG fraction purifiedwith Protein G affinity chromatorgaphy

Immunogen: Recombinant human MANF protein produced using CHO-basedIcosagen Cell factory Ltd. proprietary suspension cell line. Immunogen is purifiedfrom cell culture supernatant

Clone: 1G12

Isotype: IgG1

Application Details

Application Notes: ELISA1:32 000, Western immunoblotting 1:2000 – 1:4000. Monoclonal antibody working titer has to be established practically for each particular antigen and assay format

Comment:

Synonym: ARMET, ARP

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml

Buffer: PBS pH 7.4, with 0.1%

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles.

Storage: -20 °C

Storage Comment: This product is shipped in non-frozen liquid form in ambient conditions

Target Details for MANF

Target: MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

Alternative Name: MANF (MANF Products)

Synonyms: ARMET antibody, ARP antibody, 3230402M22Rik antibody, AA407711 antibody, AA408789 antibody, AA673178 antibody, Armet antibody, D17914 antibody, D18Mgi17 antibody, MANF antibody, RBM15B antibody, ARP-like antibody, CG7013 antibody, DmMANF antibody, Dmel\\CG7013 antibody, anon-EST:ParkEST188 antibody, arp antibody, armet antibody, im:6909481 antibody, zgc:153327 antibody, manf antibody, mesencephalic astrocyte derived neurotrophic factor antibody, mesencephalic astrocyte-derived neurotrophic factor antibody, RNA binding motif protein 15B antibody, Mesencephalic astrocyte-derived neurotrophic factor antibody, mesencephalic astrocyte-derived neurotrophic factor S homeolog antibody, MANF antibody, Manf antibody, RBM15B antibody, manf antibody, manf.S antibody

Background: MANF is a trophic factor for midbrain dopamine neuronsin vivo. It prevents the 6-OHDA-induced degeneration of dopamine neurons in rodent models of Parkinson’sdisease (Lindholm et al., 2008, Voutilainen et al., 2009). When administeredafter 6-OHDA-lesioning it restores the dopaminergic function and prevents degenerationof dopamine neurons in substantia nigra pars compacta

UniProt: P55145