EPM2A antibody (AA 131-144)

Catalog No. ABIN962654

Product Details anti-EPM2A Antibody

Target: EPM2A (Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))

Binding Specificity: AA 131-144

Reactivity: Human, Rat, Mouse, Cow, Dog, Pig, Rabbit, Monkey, Bat

Host: Goat

Clonality: Polyclonal

Conjugate: This EPM2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Brand: IHC-plus™

Specificity: Human EPM2A. This antibody is expected to recognize isoform a (NP_005661.1) only.

Predicted Reactivity: Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Panda, Bovine, Bat, Dog, Rabbit, Pig, Opossum (100%) Xenopus (93%).

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide C-EATGHTNEMKHTTD from an internal region of human EPM2A (NP_005661.1). Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Panda, Bovine, Bat, Dog, Rabbit, Pig, Opossum (100%), Xenopus (93%).

Type of Immunogen: Synthetic peptide

Application Details

Application Notes: Approved: IHC, IHC-P (2.5 - 3.75 μg/mL), Peptide-ELISA (1:16000, 0.1 - 0.3 μg/mL), WB (0.1 - 0.3 μg/mL)

Usage: Peptide ELISA: antibody detection limit dilution 1:16000. Western Blot: Approx. 38kD band observed in Human Brain (Cerebellum), Mouse Brain and Rat Brain lysates (calculated MW of 37.2kD according to NP_005661.1). Recommended concentration: 0.1-0.3 μg/mL.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Tris-buffered saline,  pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Minimize freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for EPM2A

Target: EPM2A (Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))

Alternative Name: EPM2A / Laforin (EPM2A Products)

Synonyms: TG-B antibody, Tg(TcraK,TcrbK)TG-BFlv antibody, EPM2 antibody, MELF antibody, laforin antibody, EPM2A, laforin glucan phosphatase antibody, epilepsy, progressive myoclonic epilepsy, type 2 gene alpha antibody, EPM2A antibody, Epm2a antibody

Background: Name/Gene ID: EPM2A
Subfamily: Laforin
Family: Protein Phosphatase

Synonyms: EPM2A, EPM2, LAFPTPase, LDE, Lafora PTPase, MELF, Laforin, LD

Gene ID: 7957

NCBI Accession: NP_005661

UniProt: O95278

Pathways: Cellular Glucan Metabolic Process