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IFNG antibody (Interferon gamma)

Details for Product anti-IFNG Antibody No. ABIN964736, Supplier: Log in to see
Antigen
  • IFNG2
  • IFN-g
  • Ifg
  • IFN-G
  • IFN-gamma
  • IFNG
  • IFG
  • IFI
  • interferon gamma
  • interferon gamma-like
  • interferon, gamma
  • Ifng
  • IFNG
  • LOC101337436
Alternatives
anti-Cow (Bovine) IFNG antibody for Western Blotting
Reactivity
Cow (Bovine)
718
264
144
61
37
37
32
32
31
23
22
22
22
18
17
13
13
11
10
10
10
10
9
6
5
4
2
1
1
1
Host
Rabbit
668
374
172
29
8
5
4
3
1
Clonality
Polyclonal
Conjugate
This IFNG antibody is un-conjugated
146
110
68
48
34
21
20
16
14
13
12
11
10
8
8
8
8
7
7
6
6
6
6
6
4
4
4
4
3
3
3
3
3
3
2
2
1
1
1
Application
ELISA, Western Blotting (WB)
686
646
454
164
130
127
67
67
66
63
49
38
38
24
23
20
13
12
11
9
7
5
4
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Options
Supplier
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Immunogen This protein A purified antibody was prepared prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein raised in yeast corresponding to the 143 amino acids of the mature Bovine IFN Gamma protein.
Immunogen Type: RecombinantProtein
Isotype IgG
Specificity This product was protein A purified from monospecific antiserum by chromotography. This antibody is specific for bovine IFN gamma protein. A BLAST analysis was used to suggest cross-reactivity with IFN gamma from bovine and red deer sources based on 100% homology with the immunizing sequence. Cross-reactivity with IFN gamma from other sources has not been determined.
Characteristics Interferon-gamma (IFN-gamma) is a dimerized soluble cytokine that is the only member of the type II class of interferons. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-gamma belongs. IFN-gamma, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN-gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN-gamma in the immune system stems in part from its ability to inhibit viral replication directly, but, most important, derives from its immunostimulatory and immunomodulatory effects. IFN-gamma is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.
Purification purified
Sterility Sterile filtered
Alternative Name Interferon Gamma (IFNG Antibody Abstract)
Background Interferon-gamma (IFN-gamma) is a dimerized soluble cytokine that is the only member of the type II class of interferons. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-gamma belongs. IFN-gamma, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN-gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN-gamma in the immune system stems in part from its ability to inhibit viral replication directly, but, most important, derives from its immunostimulatory and immunomodulatory effects. IFN-gamma is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.
Synonyms: BoIFNG, IFN, Interferon gamma, IFNG
Gene ID 281237
NCBI Accession NP_776511
UniProt A9QXB7
Pathways Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
Application Notes This protein A purified antibody is suitable for ELISA and Western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 16.9 kDa in size corresponding to bovine IFN gamma by western blotting in the appropriate cell lysate or extract.
Comment

Gene Name: IFN gamma

Restrictions For Research Use only
Format Liquid
Concentration 1.59 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.
Expiry Date 3 months
Supplier Images
Western Blotting (WB) image for anti-IFNG antibody (Interferon gamma) (ABIN964736) Western blot using protein-A purified anti-bovine IFN gamma antibody shows detection ...
Product cited in: Schroder, Hertzog, Ravasi, Hume: "Interferon-gamma: an overview of signals, mechanisms and functions." in: Journal of leukocyte biology, Vol. 75, Issue 2, pp. 163-89, 2004 (PubMed).