UBASH3B antibody (C-Term)

Catalog No. ABIN964881

Product Details anti-UBASH3B Antibody

Target: UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))

Binding Specificity: C-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBASH3B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Characteristics: Concentration Definition: by UV absorbance at 280 nm

Sterility: Sterile filtered

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the of mouse Sts-1.

Isotype: IgG

Application Details

Application Notes: This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.63 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-UBASH3B antibody (ABIN964881)

Carpino, Turner, Mekala, Takahashi, Zang, Geiger, Doherty, Ihle: "Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2." in: Immunity, Vol. 20, Issue 1, pp. 37-46, (2004) (PubMed).

Carpino, Kobayashi, Zang, Takahashi, Jou, Feng, Nakajima, Ihle: "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein." in: Molecular and cellular biology, Vol. 22, Issue 21, pp. 7491-500, (2002) (PubMed).

Target Details for UBASH3B

Target: UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))

Alternative Name: Sts-1 (STS1 Products)

Synonyms: STS-1 antibody, STS1 antibody, TULA-2 antibody, p70 antibody, 2810457I06Rik antibody, BB125008 antibody, RGD1310357 antibody, Sts-1 antibody, ubiquitin associated and SH3 domain containing B antibody, ubiquitin associated and SH3 domain containing, B antibody, UBASH3B antibody, Ubash3b antibody

Background: Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.  Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation.  Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2.   Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.
Synonyms: Cbl interacting protein p70 antibody, Cbl interacting protein Sts 1 antibody, Nm23 phosphorylated unknown substrate antibody, p70 antibody, SH3 domain containing 70 kDa protein antibody

Gene ID: 84959, 24497612

UniProt: Q8TF42