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ADAM17 antibody (ADAM Metallopeptidase Domain 17) (Isoform 1)

Details for Product anti-ADAM17 Antibody No. ABIN965510, Supplier: Log in to see
Antigen
  • TACE
  • adam17
  • si:dkey-81b15.2
  • adam18
  • cd156b
  • csvp
  • tace
  • CD156b
  • Tace
  • ADAM18
  • CD156B
  • CSVP
  • NISBD
Alternatives
anti-Human ADAM17 antibody for Western Blotting
Epitope
Isoform 1
83
18
14
14
14
10
7
5
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
206
66
57
2
2
1
1
1
1
1
Host
Rabbit
171
25
16
1
1
Clonality
Polyclonal
Conjugate
This ADAM17 antibody is un-conjugated
9
8
6
6
5
5
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
174
118
26
26
21
13
13
8
7
5
3
2
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ADAM17 (a disintegrin and metalloproteinase domain 17 isoform 1 preproprotein)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name ADAM17 (ADAM17 Antibody Abstract)
Background The ADAM17 (a disintegrin and metalloprotease (ADAM) domain 17) is a member of the ADAM protein family. Members of this family are membraneanchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The ADAM17 functions as a tumor necrosis factor-alpha converting enzyme.It binds mitotic arrest deficient 2 protein and also plays a prominent role in the activation of the Notch signaling pathway.
Research Area Cancer, Proteolysis / Ubiquitin, Metalloprotease, Alzheimer's Disease
Pathways Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Shao, Nadel: "Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 3, pp. 767-72, 2005 (PubMed).

Shao, Ueki, Nadel: "Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 20, pp. 11618-23, 2003 (PubMed).

Gschwind, Hart, Fischer et al.: "TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells." in: The EMBO journal, Vol. 22, Issue 10, pp. 2411-21, 2003 (PubMed).

Background publications Rabie, Strehl, Ludwig et al.: "Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V." in: The Journal of biological chemistry, Vol. 280, Issue 15, pp. 14462-8, 2005 (PubMed).

Schäfer, Marg, Gschwind et al.: "Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival." in: The Journal of biological chemistry, Vol. 279, Issue 46, pp. 47929-38, 2004 (PubMed).

Lee, Rapti, Murphy: "Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 45121-9, 2004 (PubMed).

Allinson, Parkin, Condon et al.: "The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein." in: European journal of biochemistry / FEBS, Vol. 271, Issue 12, pp. 2539-47, 2004 (PubMed).

Solomon, Rosenblum, Gonzales et al.: "Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-alpha-converting enzyme and matrix metalloproteinases despite their high ..." in: The Journal of biological chemistry, Vol. 279, Issue 30, pp. 31646-54, 2004 (PubMed).

Valeva, Walev, Weis et al.: "A cellular metalloproteinase activates Vibrio cholerae pro-cytolysin." in: The Journal of biological chemistry, Vol. 279, Issue 24, pp. 25143-8, 2004 (PubMed).

Peiretti, Deprez-Beauclair, Bonardo et al.: "Identification of SAP97 as an intracellular binding partner of TACE." in: Journal of cell science, Vol. 116, Issue Pt 10, pp. 1949-57, 2003 (PubMed).

Díaz-Rodríguez, Montero, Esparís-Ogando et al.: "Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding." in: Molecular biology of the cell, Vol. 13, Issue 6, pp. 2031-44, 2002 (PubMed).

Cerretti, Poindexter, Castner et al.: "Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25." in: Cytokine, Vol. 11, Issue 8, pp. 541-51, 1999 (PubMed).