Apolipoprotein A-V (APOA5) antibody

Details for Product No. ABIN965569, Supplier: Log in to see
Antigen
  • APOA5
  • MGC140487
  • rap3
  • apoav
  • apoa-v
  • APOAV
  • RAP3
  • apo-AV
  • apoA-V
  • 1300007O05Rik
  • Apoav
  • apolipoprotein A-V
  • apolipoprotein A5
  • APOA5
  • apoa5
  • Apoa5
Alternatives
anti-Human Apolipoprotein A-V antibody for Cytometry by Time of Flight
Reactivity
Human
224
28
24
17
7
3
1
Host
155
68
16
Clonality
Monoclonal
Conjugate
Un-conjugated
12
9
8
6
6
6
5
5
5
4
4
4
4
4
4
4
3
3
2
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
170
159
46
36
33
25
20
13
8
4
3
2
2
1
1
Options
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Isotype IgG1
Specificity Ni-NTA purified recombinant human Apoa5 expressed in E. Coli strain BL21 (DE3).
Purification Antibodies are purified by protein G affinity chromatography.
Alternative Name APOA5 (APOA5 Antibody Abstract)
Background Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor- agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Despite these compelling molecular biology data, relatively little is known about ApoA5 protein in human serum. This antibody pair detected recombinant apoa5 protein in sandwich ELISA format and could be potential reagents for the development of clinical diagnostic kits.
Gene ID 116519
Pathways Regulation of Lipid Metabolism by PPARalpha
Application Notes Western Blot: Dilution 1: 1,000- 1: 2,000
Suggested ELISA dilution 1: 4,000
ptimized dilution must be determined by end user.
Restrictions For Research Use only
Storage -20 °C
Background publications Prieur, Coste, Rodriguez: "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25468-80, 2003 (PubMed).

Pennacchio, Olivier, Hubacek, Cohen, Cox, Fruchart, Krauss, Rubin: "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing." in: Science (New York, N.Y.), Vol. 294, Issue 5540, pp. 169-73, 2001 (PubMed).