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Apolipoprotein A-V (APOA5) (N-Term) antibody

Details for Product No. ABIN965570, Supplier: Log in to see
Antigen
  • 1300007O05Rik
  • apo-AV
  • apoa-v
  • apoA-V
  • APOA5
  • Apoav
  • APOAV
  • apoav
  • MGC140487
  • rap3
  • RAP3
Epitope
N-Term
19
14
6
5
5
3
3
3
2
2
2
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
164
24
20
7
2
1
1
Host
Rabbit
105
57
14
Clonality
Polyclonal
Conjugate
Un-conjugated
8
7
4
4
4
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
128
114
21
20
11
9
6
5
4
2
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human APOA5 (Apolipoprotein A-V precursor)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name APOA5 (APOA5 Antibody Abstract)
Background APOA5(Apolipoprotein A-V) is a minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. APOA5 may also be associated with chylomicrons. APOA5 is an important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDLTG production rate (without affecting the VLDL-apoB production rate). Three common alleles are known: allele APOA5*1, APOA5*2 and APOA5*3. The APOA5*2 haplotype, which consists of 3 non-coding SNPs, is present in approximately 16% of Caucasians and is associated with increased plasma triglyceride concentrations. APOA5*3 haplotype is defined by the rare Ser-19-Trp substitution. Together, the APOA5*2 and APOA5*3 haplotypes are found in 25 to 50% of African Americans, Hispanics, and Caucasians.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Fullerton, Buchanan, Sonpar, Taylor, Smith, Carlson, Salomaa, Stengård, Boerwinkle, Clark, Nickerson, Weiss: "The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster." in: Human genetics, Vol. 115, Issue 1, pp. 36-56, 2004 (PubMed).

Prieur, Coste, Rodriguez: "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25468-80, 2003 (PubMed).

Weinberg, Cook, Beckstead, Martin, Gallagher, Shelness, Ryan: "Structure and interfacial properties of human apolipoprotein A-V." in: The Journal of biological chemistry, Vol. 278, Issue 36, pp. 34438-44, 2003 (PubMed).

Beckstead, Oda, Martin, Forte, Bielicki, Berger, Luty, Kay, Ryan: "Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis." in: Biochemistry, Vol. 42, Issue 31, pp. 9416-23, 2003 (PubMed).

van der Vliet, Sammels, Leegwater, Levels, Reitsma, Boers, Chamuleau: "Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration." in: The Journal of biological chemistry, Vol. 276, Issue 48, pp. 44512-20, 2001 (PubMed).

Pennacchio, Olivier, Hubacek, Cohen, Cox, Fruchart, Krauss, Rubin: "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing." in: Science (New York, N.Y.), Vol. 294, Issue 5540, pp. 169-73, 2001 (PubMed).