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Amyloid beta (A4) Precursor Protein (APP) (AA 18-32), (N-Term) antibody

Details for Product No. ABIN965581, Supplier: Login to see
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
Alternatives
anti-Human Amyloid beta (A4) Precursor Protein antibody for Enzyme Immunoassay
Epitope
N-Term, AA 18-32
122
108
52
35
25
20
19
17
17
15
15
14
14
14
13
11
10
8
8
8
6
6
6
5
5
5
5
5
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus)
823
307
277
41
11
9
8
8
6
3
2
2
1
1
1
1
Host
580
223
50
3
2
Clonality
Polyclonal
Conjugate
Un-conjugated
48
37
35
17
13
13
13
13
13
13
13
13
12
11
11
2
2
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
563
316
231
149
147
75
57
33
29
20
15
10
9
8
6
3
2
2
2
2
1
Supplier
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Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human APP (18-32 aa), identical to the related mouse and rat sequence.
Alternative Name APP (APP Antibody Abstract)
Background Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates beta amyloid (A), a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. APP undergoes posttranslational proteolytic processing by alpha-, beta-, and gamma-secretases. Alpha-secretase generates soluble amyloid protein, while beta- and gamma-secretases generate APP components with amyloidogenic features. These 2 processing pathways are mutually exclusive.
Research Area Signaling
Pathways Caspase Cascade in Apoptosis, EGFR Signaling Pathway
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Duce, Tsatsanis, Cater et al.: "Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease." in: Cell, Vol. 142, Issue 6, pp. 857-67, 2010 (PubMed).

Priller, Bauer, Mitteregger et al.: "Synapse formation and function is modulated by the amyloid precursor protein." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 27, pp. 7212-21, 2006 (PubMed).

Wang, Ha: "The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain." in: Molecular cell, Vol. 15, Issue 3, pp. 343-53, 2004 (PubMed).

Turner, OConnor, Tate et al.: "Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory." in: Progress in neurobiology, Vol. 70, Issue 1, pp. 1-32, 2003 (PubMed).