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APP antibody (Amyloid beta (A4) Precursor Protein) (N-Term)

Details for Product anti-APP Antibody No. ABIN965581, Supplier: Log in to see
Antigen
  • aaa
  • AAA
  • abeta
  • ABETA
  • Abeta
  • abpp
  • Abpp
  • ABPP
  • ad1
  • AD1
  • Adap
  • Ag
  • APP
  • app
  • APP-like
  • APPI
  • appi
  • appl
  • APPL
  • BcDNA:GH04413
  • betaApp
  • CG7727
  • ctfgamma
  • CTFgamma
  • Cvap
  • CVAP
  • cvap
  • Dmel\\CG7727
  • E030013M08Rik
  • EG:65F1.5
  • PN-II
  • PN2
  • pn2
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
Alternatives
anti-Human APP antibody for Enzyme Immunoassay
Epitope
N-Term, AA 18-32
105
104
61
36
26
25
22
19
17
15
15
14
14
14
12
11
10
8
7
6
6
6
5
5
5
5
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus)
816
306
283
29
11
10
6
6
4
3
2
2
1
1
1
1
Host
579
220
46
3
2
Clonality
Polyclonal
Conjugate
This APP antibody is un-conjugated
47
37
36
24
13
13
13
12
12
12
12
12
12
11
11
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
564
321
236
144
133
89
48
31
31
20
15
10
9
8
6
3
2
2
2
1
Supplier
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Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human APP (18-32 aa), identical to the related mouse and rat sequence.
Alternative Name APP (APP Antibody Abstract)
Background Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates beta amyloid (A), a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. APP undergoes posttranslational proteolytic processing by alpha-, beta-, and gamma-secretases. Alpha-secretase generates soluble amyloid protein, while beta- and gamma-secretases generate APP components with amyloidogenic features. These 2 processing pathways are mutually exclusive.
Research Area Signaling
Pathways Caspase Cascade in Apoptosis, EGFR Signaling Pathway
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Duce, Tsatsanis, Cater, James, Robb, Wikhe, Leong, Perez, Johanssen, Greenough, Cho, Galatis, Moir, Masters, McLean, Tanzi, Cappai, Barnham, Ciccotosto, Rogers, Bush: "Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease." in: Cell, Vol. 142, Issue 6, pp. 857-67, 2010 (PubMed).

Priller, Bauer, Mitteregger, Krebs, Kretzschmar, Herms: "Synapse formation and function is modulated by the amyloid precursor protein." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 27, pp. 7212-21, 2006 (PubMed).

Wang, Ha: "The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain." in: Molecular cell, Vol. 15, Issue 3, pp. 343-53, 2004 (PubMed).

Turner, OConnor, Tate, Abraham: "Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory." in: Progress in neurobiology, Vol. 70, Issue 1, pp. 1-32, 2003 (PubMed).