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Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (pSer83) antibody

Details for Product No. ABIN965598
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Antigen
Synonyms 7420452D20Rik, ASK, ASK1, MAPKKK5, Mekk5, mitogen-activated protein kinase kinase kinase 5, MUD21.11, MUD21_11, MEKK5, MAP3K5
Epitope
pSer83
(45), (37), (33), (16), (12), (12), (12), (12), (10), (7), (7), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(305), (127), (74), (36), (24), (12), (1)
Host
Rabbit
(288), (19)
Conjugate
Un-conjugated
(10), (10), (10), (6), (6), (6), (6), (6), (6), (6), (6), (4), (4), (4)
Application
Immunohistochemistry (IHC)
(222), (114), (103), (60), (59), (31), (29), (7), (5), (4), (3), (3), (1), (1), (1)
Pubmed 3 references available
Quantity 100 µg
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Catalog No. ABIN965598
385.00 $
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human ASK1 around the phosphorylation site of serine 83 (G-S-SP-V-G).
Specificity ASK1 (phospho-Ser83) antibody detects endogenous levels of ASK1 only when phosphorylated at serine 83.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.
Alternative Name ASK1
Research Area Cardiovascular, Hypertrophy, Apoptosis/Necrosis
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Kim, Khursigara, Sun et al.: "Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1." in: Molecular and cellular biology, Vol. 21, Issue 3, pp. 893-901, 2001 (PubMed).

Yuan, Feldman, Sussman et al.: "AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23432-40, 2003 (PubMed).

Mabuchi, Ohmichi, Kimura et al.: "Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines." in: Endocrinology, Vol. 145, Issue 1, pp. 49-58, 2003 (PubMed).

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