anti-MAP3K5 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 5) (pSer83)

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Antigen
Synonyms 7420452D20Rik, ASK, ASK1, MAPKKK5, Mekk5, mitogen-activated protein kinase kinase kinase 5, MUD21.11, MUD21_11, MEKK5, MAP3K5
Alternatives
Epitope
pSer83
(54), (48), (40), (25), (23), (19), (16), (15), (13), (13), (13), (9), (8), (6), (6), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(382), (143), (78), (3), (1)
Host
Rabbit
(367), (24)
Conjugate
This MAP3K5 antibody is un-conjugated
(12), (12), (11), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5)
Application
Immunohistochemistry (IHC)
(302), (156), (134), (62), (56), (43), (24), (11), (7), (7), (6), (2), (1), (1), (1)
Pubmed 3 references available
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Quantity 100 μg
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human ASK1 around the phosphorylation site of serine 83 (G-S-SP-V-G).
Specificity ASK1 (phospho-Ser83) antibody detects endogenous levels of ASK1 only when phosphorylated at serine 83.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.
Alternative Name ASK1 (MAP3K5 Antibody Abstract)
Research Area Cardiovascular, Hypertrophy, Apoptosis/Necrosis
Pathways MAPK Signaling
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Mabuchi, Ohmichi, Kimura et al.: "Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines." in: Endocrinology, Vol. 145, Issue 1, pp. 49-58, 2003 (PubMed).

Kim, Khursigara, Sun et al.: "Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1." in: Molecular and cellular biology, Vol. 21, Issue 3, pp. 893-901, 2001 (PubMed).

Background publications Yuan, Feldman, Sussman et al.: "AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23432-40, 2003 (PubMed).

Catalog No. ABIN965598
$398.75
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