Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (pSer966) antibody

Details for Product No. ABIN965599
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Antigen
Synonyms 7420452D20Rik, ASK, ASK1, MAPKKK5, Mekk5, mitogen-activated protein kinase kinase kinase 5, MUD21.11, MUD21_11, MEKK5, MAP3K5
Epitope
pSer966
(47), (37), (33), (16), (12), (12), (12), (12), (10), (7), (7), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(309), (128), (77), (36), (24), (12), (1)
Host
Rabbit
(292), (19)
Conjugate
Un-conjugated
(10), (10), (10), (6), (6), (6), (6), (6), (6), (6), (6), (4), (4), (4)
Application
Immunohistochemistry (IHC)
(226), (118), (106), (60), (59), (31), (29), (7), (5), (4), (3), (3), (1), (1), (1)
Pubmed 3 references available
Quantity 100 µg
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Catalog No. ABIN965599
385.00 $
Plus shipping costs $45.00

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  • +1 404 474 4654
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human ASK1 around the phosphorylation site of serine 966 (S-I-SP-L-P).
Specificity ASK1 (phospho-Ser966) antibody detects endogenous levels of ASK1 only when phosphorylated at serine 966.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name ASK1
Research Area Cardiovascular, Hypertrophy, Apoptosis/Necrosis
Application Notes IHC: 1:50~1:100
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Goldman, Chen, Fu: "Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dissociation." in: The Journal of biological chemistry, Vol. 279, Issue 11, pp. 10442-9, 2004 (PubMed).

Fujii, Goldman, Park et al.: "Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034." in: Oncogene, Vol. 23, Issue 29, pp. 5099-104, 2004 (PubMed).

Zhang, Zheng, Storz et al.: "Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor." in: The Journal of biological chemistry, Vol. 280, Issue 19, pp. 19036-44, 2005 (PubMed).

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