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MAP3K5 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 5) (pSer966)

Details for Product anti-MAP3K5 Antibody No. ABIN965599, Supplier: Login to see
Antigen
  • 7420452D20Rik
  • ASK
  • ASK1
  • MAPKKK5
  • Mekk5
  • mitogen-activated protein kinase kinase kinase 5
  • MUD21.11
  • MUD21_11
  • MEKK5
  • MAP3K5
Alternatives
anti-Human MAP3K5 antibody for Western Blotting
Epitope
pSer966
55
44
40
24
22
20
17
15
13
13
13
9
8
6
5
4
4
4
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
371
137
78
4
1
Host
Rabbit
357
22
Conjugate
This MAP3K5 antibody is un-conjugated
12
12
11
6
6
6
6
5
5
5
5
5
5
5
5
Application
Immunohistochemistry (IHC)
291
146
127
57
56
39
23
11
7
6
6
2
1
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human ASK1 around the phosphorylation site of serine 966 (S-I-SP-L-P).
Specificity ASK1 (phospho-Ser966) antibody detects endogenous levels of ASK1 only when phosphorylated at serine 966.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name ASK1 (MAP3K5 Antibody Abstract)
Research Area Cardiovascular, Hypertrophy, Apoptosis/Necrosis
Pathways MAPK Signaling
Application Notes IHC: 1:50~1:100
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Zhang, Zheng, Storz et al.: "Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor." in: The Journal of biological chemistry, Vol. 280, Issue 19, pp. 19036-44, 2005 (PubMed).

Fujii, Goldman, Park et al.: "Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034." in: Oncogene, Vol. 23, Issue 29, pp. 5099-104, 2004 (PubMed).

Goldman, Chen, Fu: "Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dissociation." in: The Journal of biological chemistry, Vol. 279, Issue 11, pp. 10442-9, 2004 (PubMed).