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Ataxia Telangiectasia Mutated (ATM) (pSer1981) antibody

Antigen

Ataxia Telangiectasia Mutated (ATM)
Synonyms AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, DKFZp781A0353, AI256621, C030026E19Rik, ATM, Tefu, atm/tefu, dATM, tef, DmelCG6535, CG6535, Xatm
Binding Site
Alternatives

pSer1981
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC)
4 references available
Catalog no. ABIN965619
Quantity 100ug  (100ug/100ul.)  (Variants)
Price 385.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name ATM
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human ATM around the phosphorylation site of serine 1981 (E-G-SP-Q-S).
Specificity ATM (phospho-Ser1981) antibody detects endogenous levels of ATM only when phosphorylated at serine 1981.

Application Details
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Application Notes IHC: 1:50-1:100.
Concentration 100ug/100ul.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative 0.02% Sodium Azide
Storage Store at -20°C/1 year.
Research Area Cancer, DNA/RNA
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Product Bernstein, Seminara, Børresen-Dale: "Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002." in: Breast cancer research : BCR, Vol. 4, Issue 6, pp. 249-52, 2002 (PubMed).

Nakada, Shimomura, Matsumoto et al.: "The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment." in: Nucleic acids research, Vol. 31, Issue 6, pp. 1715-24, 2003 (PubMed).

Silverman, Takai, Buonomo et al.: "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint." in: Genes & development, Vol. 18, Issue 17, pp. 2108-19, 2004 (PubMed).

Gupta, Sharma, Young et al.: "Involvement of human MOF in ATM function." in: Molecular and cellular biology, Vol. 25, Issue 12, pp. 5292-305, 2005 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Ataxia Telangiectasia Mutated (ATM)", type "Antibodies"
Hosts Rabbit (90), Mouse (32), Goat (8), Sheep (5), Chicken (2)
Reactivities Human (131), Mouse (Murine) (61), Rat (Rattus) (43), Hamster (2), Monkey (2)
Applications Western Blotting (WB) (67), Immunofluorescence (IF) (45), ELISA (28), Immunoprecipitation (IP) (28), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (23), Immunohistochemistry (IHC) (17), Immunocytochemistry (ICC) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Fluorescence Microscopy (FM) (5), Dot Blot (Dot) (2), Flow Cytometry (FACS) (2), Immunoelectron Microscopy (IEM) (2), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), Biotin (3), HRP (3), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), PE (2), PE,Cy5.5 (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1)
Epitopes pSer1981 (20), pTyr170 (18), AA 2577-3056 (4), AA 1-308 (3), AA 1391-1693 (3), AA 1980-2338 (3), AA 980-1512 (3), Ser1981 (3), pSer1981,AA 1974-1988 (3), C-Term (2), N-Term (2), AA 1248-1332 (1), AA 1653-2032 (1), AA 1750-1800 (1), AA 2050-2717 (1), AA 2550-2600 (1), AA 5055-6585 (1), Internal Region (1)