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ATM antibody (Ataxia Telangiectasia Mutated) (pSer1981)

Details for Product anti-ATM Antibody No. ABIN965619, Supplier: Login to see
Antigen
  • ATM
  • Atm
  • CG6535
  • Dmel\\CG6535
  • Tefu
  • atm
  • atm/tefu
  • dATM
  • tef
  • Xatm
  • at1
  • atdc
  • tel1
  • telo1
  • AT1
  • ATA
  • ATC
  • ATD
  • ATDC
  • ATE
  • TEL1
  • TELO1
  • AI256621
  • C030026E19Rik
Alternatives
anti-Human ATM antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
pSer1981
75
22
17
15
13
13
8
8
7
6
5
5
4
4
4
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
296
73
30
6
4
1
1
Host
Rabbit
212
58
16
8
4
Conjugate
This ATM antibody is un-conjugated
8
8
6
6
6
6
4
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC)
171
79
70
52
42
41
25
22
16
11
5
4
4
2
2
1
1
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human ATM around the phosphorylation site of serine 1981 (E-G-SP-Q-S).
Specificity ATM (phospho-Ser1981) antibody detects endogenous levels of ATM only when phosphorylated at serine 1981.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name ATM (ATM Antibody Abstract)
Research Area Cancer, DNA/RNA
Pathways p53 Signaling, Apoptosis, DNA Damage Repair
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Nakada, Shimomura, Matsumoto et al.: "The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment." in: Nucleic acids research, Vol. 31, Issue 6, pp. 1715-24, 2003 (PubMed).

Bernstein, Seminara, Børresen-Dale: "Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002." in: Breast cancer research : BCR, Vol. 4, Issue 6, pp. 249-52, 2002 (PubMed).

Background publications Gupta, Sharma, Young et al.: "Involvement of human MOF in ATM function." in: Molecular and cellular biology, Vol. 25, Issue 12, pp. 5292-305, 2005 (PubMed).

Silverman, Takai, Buonomo et al.: "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint." in: Genes & development, Vol. 18, Issue 17, pp. 2108-19, 2004 (PubMed).