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AXL antibody (AXL Receptor tyrosine Kinase) (C-Term)

Details for Product anti-AXL Antibody No. ABIN965631, Supplier: Log in to see
Antigen
  • AI323647
  • Ark
  • JTK11
  • Tyro7
  • Ufo
  • UFO
Alternatives
anti-Human AXL antibody for Western Blotting
Epitope
C-Term
37
27
16
15
15
14
14
12
9
8
6
6
5
5
5
4
4
4
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
214
72
53
3
Host
Rabbit
159
63
11
2
1
Clonality
Polyclonal
Conjugate
This AXL antibody is un-conjugated
11
9
9
8
7
6
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4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
162
102
55
55
26
22
15
7
7
6
2
1
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human AXL(Tyrosine-protein kinase receptor UFO)
Alternative Name AXL (AXL Antibody Abstract)
Background AXL(Tyrosine-protein kinase receptor UFO) may function as a signal transducer between specific cell types of mesodermal origin. In case of filovirus infection, AXL seems to function as a cell entry factor. AXL is heterodimer and heterotetramer with GAS6. AXL is a single-pass type I membrane protein. It is highly expressed in metastatic colon tumors. And weakly expressed in normal colon tissue. AXL belongs to the protein kinase superfamily and Tyr protein kinase family and AXL/UFO subfamily. AXL contains 1 protein kinase domain.
Synonyms: UFO
Pathways RTK Signaling
Restrictions For Research Use only
Background publications Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007

Product cited in: Shimojima, Takada, Ebihara, Neumann, Fujioka, Irimura, Jones, Feldmann, Kawaoka: "Tyro3 family-mediated cell entry of Ebola and Marburg viruses." in: Journal of virology, Vol. 80, Issue 20, pp. 10109-16, 2006

Craven, Xu, Weiner, Fridell, Dent, Srivastava, Varnum, Liu, Cance: "Receptor tyrosine kinases expressed in metastatic colon cancer." in: International journal of cancer. Journal international du cancer, Vol. 60, Issue 6, pp. 791-7, 1995

Lee, Strunk, Spritz: "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes." in: Oncogene, Vol. 8, Issue 12, pp. 3403-10, 1993

Partanen, Mäkelä, Alitalo, Lehväslaiho, Alitalo: "Putative tyrosine kinases expressed in K-562 human leukemia cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 22, pp. 8913-7, 1991

OBryan, Frye, Cogswell, Neubauer, Kitch, Prokop, Espinosa, Le Beau, Earp, Liu: "axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase." in: Molecular and cellular biology, Vol. 11, Issue 10, pp. 5016-31, 1991

Janssen, Schulz, Steenvoorden, Schmidberger, Strehl, Ambros, Bartram: "A novel putative tyrosine kinase receptor with oncogenic potential." in: Oncogene, Vol. 6, Issue 11, pp. 2113-20, 1991