AXL antibody (AXL Receptor tyrosine Kinase) (C-Term)

Details for Product anti-AXL Antibody No. ABIN965632, Supplier: Log in to see
Antigen
  • JTK11
  • UFO
  • AI323647
  • Ark
  • Tyro7
  • Ufo
  • AXL receptor tyrosine kinase
  • Axl receptor tyrosine kinase
  • AXL
  • Axl
Alternatives
anti-Human AXL antibody for Immunofluorescence (fixed cells)
Epitope
C-Term, pTyr698, pTyr702, pTyr703
27
24
18
17
17
16
14
12
12
11
10
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8
6
6
6
6
5
5
5
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4
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
245
92
63
6
2
2
1
1
1
1
Host
Rabbit
173
80
20
4
1
Clonality
Polyclonal
Conjugate
This AXL antibody is un-conjugated
14
11
9
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6
6
6
6
6
6
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4
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC)
172
109
107
53
30
26
14
10
7
6
2
2
2
1
1
1
1
1
1
Options
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human AXL(Tyrosine-protein kinase receptor UFO)
Alternative Name AXL (AXL Antibody Abstract)
Background AXL(Tyrosine-protein kinase receptor UFO) may function as a signal transducer between specific cell types of mesodermal origin. In case of filovirus infection, AXL seems to function as a cell entry factor. AXL is heterodimer and heterotetramer with GAS6. AXL is a single-pass type I membrane protein. It is highly expressed in metastatic colon tumors. And weakly expressed in normal colon tissue. AXL belongs to the protein kinase superfamily and Tyr protein kinase family and AXL/UFO subfamily. AXL contains 1 protein kinase domain.
Pathways RTK Signaling, Cellular Response to Molecule of Bacterial Origin
Restrictions For Research Use only
Background publications Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Product cited in: Shimojima, Takada, Ebihara, Neumann, Fujioka, Irimura, Jones, Feldmann, Kawaoka: "Tyro3 family-mediated cell entry of Ebola and Marburg viruses." in: Journal of virology, Vol. 80, Issue 20, pp. 10109-16, 2006 (PubMed).

Craven, Xu, Weiner, Fridell, Dent, Srivastava, Varnum, Liu, Cance: "Receptor tyrosine kinases expressed in metastatic colon cancer." in: International journal of cancer. Journal international du cancer, Vol. 60, Issue 6, pp. 791-7, 1995 (PubMed).

Lee, Strunk, Spritz: "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes." in: Oncogene, Vol. 8, Issue 12, pp. 3403-10, 1993 (PubMed).

Partanen, Mäkelä, Alitalo, Lehväslaiho, Alitalo: "Putative tyrosine kinases expressed in K-562 human leukemia cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 22, pp. 8913-7, 1991 (PubMed).

OBryan, Frye, Cogswell, Neubauer, Kitch, Prokop, Espinosa, Le Beau, Earp, Liu: "axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase." in: Molecular and cellular biology, Vol. 11, Issue 10, pp. 5016-31, 1991 (PubMed).

Janssen, Schulz, Steenvoorden, Schmidberger, Strehl, Ambros, Bartram: "A novel putative tyrosine kinase receptor with oncogenic potential." in: Oncogene, Vol. 6, Issue 11, pp. 2113-20, 1991 (PubMed).