BAD antibody (BCL2-Associated Agonist of Cell Death) (pSer112)

Details for Product anti-BAD Antibody No. ABIN965635, Supplier: Log in to see
Antigen
  • bad
  • fa01b12
  • wu:fa01b12
  • wu:fa96d04
  • BAD
  • BBC2
  • BCL2L8
  • AI325008
  • Bbc2
  • BCL2-antagonist of cell death b
  • BCL2-associated agonist of cell death
  • badb
  • BAD
  • Bad
Alternatives
anti-Mouse (Murine) BAD antibody for Immunohistochemistry (Frozen Sections)
Epitope
pSer112
60
57
52
49
47
45
43
29
22
21
21
20
20
20
20
20
20
20
20
20
20
20
20
20
20
19
19
19
19
15
15
12
10
9
8
8
7
5
5
5
5
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
779
434
264
19
15
8
5
4
3
2
2
1
1
1
1
1
1
Host
Rabbit
957
49
2
1
Conjugate
This BAD antibody is un-conjugated
65
64
64
58
58
58
6
6
6
6
6
6
6
6
6
6
6
Application
Immunohistochemistry (IHC)
527
465
396
294
114
79
53
29
13
12
6
5
4
3
2
1
1
1
Options
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human BAD around the phosphorylation site of serine 112 (H-S-SP-Y-P).
Specificity BAD (phospho-Ser112) phosphorylated at serine 112.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name BAD (BAD Antibody Abstract)
Research Area Apoptosis/Necrosis
Pathways MAPK Signaling, PI3K-Akt Signaling, RTK Signaling, Apoptosis, Fc-epsilon Receptor Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Zhang, Zhang, Shacter: "Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75." in: Molecular and cellular biology, Vol. 24, Issue 14, pp. 6205-14, 2004 (PubMed).

Product cited in: Rice, Washington, Schleman, Beard, Driggers, Ahnen: "Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells." in: Cancer research, Vol. 63, Issue 3, pp. 616-20, 2003 (PubMed).

Wang, Sun, Paller: "Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosis." in: The Journal of biological chemistry, Vol. 276, Issue 48, pp. 44504-11, 2001 (PubMed).

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