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BCL (pSer70) antibody
Alternatives Immunohistochemistry (IHC)
|3 references available|
|Price||385.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||The antiserum was produced against synthesized phosphopeptide derived from human BCL-2 around the phosphorylation site of serine 70 (R-T-SP-P-L).|
|Specificity||BCL-2 (phospho-Ser70) antibody detects endogenous levels of BCL-2 only when phosphorylated at serine 70.|
|Application Notes||IHC: 1:50-1:100.|
|Buffer||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol|
|Preservative||0.02% Sodium Azide|
|Storage||Store at -20°C/1 year.|
|Restrictions||For Research Use only|
Yamamoto, Ichijo, Korsmeyer: "BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M." in: Molecular and cellular biology, Vol. 19, Issue 12, pp. 8469-78, 2000 (PubMed).
Huang, Cidlowski: "Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 8, pp. 825-32, 2002 (PubMed).
Jin, Gao, Flagg et al.: "Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 40209-19, 2004 (PubMed).