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beta Catenin antibody (Catenin, beta) (pSer33)

Details for Product anti-Catenin, beta Antibody No. ABIN965659, Supplier: Log in to see
Antigen
  • armadillo
  • beta-catenin
  • Bfc
  • Catnb
  • CHBCAT
  • CTNNB
  • ctnnb
  • ctnnb1
  • id:ibd2058
  • Mesc
  • MRD19
  • wu:fb73e10
  • wu:fi81c06
  • wu:fk25h01
Epitope
pSer33
39
36
30
29
22
21
19
15
15
14
13
13
12
5
5
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
347
256
239
17
15
11
10
10
10
9
5
5
4
3
1
Host
Rabbit
304
46
4
Conjugate
This beta Catenin antibody is un-conjugated
11
11
9
9
9
9
9
9
9
9
9
8
1
1
1
1
Application
Immunohistochemistry (IHC)
236
104
101
79
44
39
38
16
13
9
5
2
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human -Catenin around the phosphorylation site of serine 33 (L-D-SP-G-I).
Specificity -Catenin (phospho-Ser33) antibody detects endogenous levels of -Catenin only when phosphorylated at serine 33.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.
Alternative Name beta-Catenin
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Okamura, Garcia-Rodriguez, Martinson, Qin, Virshup, Rao: "A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1." in: Molecular and cellular biology, Vol. 24, Issue 10, pp. 4184-95, 2004

Marin, Bustos, Cesaro, Meggio, Pagano, Antonelli, Allende, Pinna, Allende: "A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 18, pp. 10193-200, 2003

Product cited in: Xing, Clements, Kimelman, Xu: "Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex." in: Genes & development, Vol. 17, Issue 22, pp. 2753-64, 2003

Novak, Hsu, Leung-Hagesteijn, Radeva, Papkoff, Montesano, Roskelley, Grosschedl, Dedhar: "Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 8, pp. 4374-9, 1998