BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (pSer69)

Details for Product anti-BCL2L11 Antibody No. ABIN965668, Supplier: Log in to see
Antigen
  • bim
  • BAM
  • BIM
  • BOD
  • 1500006F24Rik
  • Bim
  • Bod
  • BimL
  • BIMEL
  • BCL2-like 11
  • BCL2-like 11 (apoptosis facilitator)
  • bcl2l11
  • LOC100345483
  • BCL2L11
  • Bcl2l11
Alternatives
anti-Human BIM antibody for ELISA
Epitope
pSer69, pSer65
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Conjugate
This BIM antibody is un-conjugated
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Application
Immunohistochemistry (IHC)
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Options
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human BIM around the phosphorylation site of serine 69 (P-A-SP-P-G).
Specificity BIM (phospho-Ser69/65) antibody detects endogenous levels of BIM only when phosphorylated at serine 69/65.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.
Alternative Name BIM (BCL2L11 Antibody Abstract)
Pathways PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Fukazawa, Noguchi, Masumi, Murakami, Uehara: "BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors." in: Molecular cancer therapeutics, Vol. 3, Issue 10, pp. 1281-8, 2004 (PubMed).

Luciano, Jacquel, Colosetti, Herrant, Cagnol, Pages, Auberger: "Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function." in: Oncogene, Vol. 22, Issue 43, pp. 6785-93, 2003 (PubMed).

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