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Details for Product No. ABIN965689

BMX Non-Receptor Tyrosine Kinase (BMX) (Cytoplasmic), (C-Term), (pTyr566) antibody

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Antigen
Synonyms ETK, PSCTK2, PSCTK3, Etk, Tyro8, Etk/Bmx, RGD1565643, BMX
Epitope
»Alternatives Cytoplasmic, C-Term, pTyr566
Reactivity
»Alternatives Human, Mouse (Murine)
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN965689
Quantity 0.1 mg
Price
452.38 $   Plus shipping costs $45.00
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human BMX (Cytoplasmic tyrosine-protein kinase BMX or Bone marrow tyrosine kinase gene in chromosome X protein)
Alternative Name BMX
Background The activity of BMX (Cytoplasmic tyrosine-protein kinase BMX or Bone marrow tyrosine kinase gene in chromosome X protein) is required for interleukin 6 (IL-6) induced differentiation. BMX may play a role in the growth and differentiation of hematopoietic cells. BMX may be involved in signal transduction in endocardial and arterial endothelial cells. BMX binds 1 zinc ion per subunit and interacts with RUFY1 and RUFY2. BMX is preferentially expressed in epithelial and endothelial cells. BMX is activated by IL-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the PH domain. SH2 domain mediates interaction with RUFY1 and BMX belongs to the protein kinase superfamily, Tyr protein kinase family and TEC subfamily.
Synonyms: ETK (Epithelial and endothelial tyrosine kinase)
Research Area Signaling, Tyrosine Kinases
Restrictions For Research Use only
Product cited in: Tamagnone, Lahtinen, Mustonen et al.: "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2." in: Oncogene, Vol. 9, Issue 12, pp. 3683-8, 1994 (PubMed).

Qiu, Robinson, Pretlow et al.: "Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 7, pp. 3644-9, 1998 (PubMed).

Yang, Kim, Wu et al.: "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking." in: The Journal of biological chemistry, Vol. 277, Issue 33, pp. 30219-26, 2002 (PubMed).

Nore, Mattsson, Antonsson et al.: "Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases." in: Biochimica et biophysica acta, Vol. 1645, Issue 2, pp. 123-32, 2003 (PubMed).

Alternatives for antigen "BMX Non-Receptor Tyrosine Kinase (BMX)", type "Antibodies"
Hosts (100), (9)
Reactivities (108), (89), (53), (48), (48), (48)
Applications (71), (49), (40), (29), (24), (21), (6), (3), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (18), (17), (12), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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