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BMX Non-Receptor Tyrosine Kinase (BMX) (Cytoplasmic,C-Term,pTyr566) antibody
|Synonyms||ETK, PSCTK2, PSCTK3, Etk, Tyro8, Etk/Bmx, RGD1565643, BMX|
Human, Mouse (Murine)
Alternatives Immunohistochemistry (IHC)
|4 references available|
|Price||452.38 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human BMX (Cytoplasmic tyrosine-protein kinase BMX or Bone marrow tyrosine kinase gene in chromosome X protein)|
The activity of BMX (Cytoplasmic tyrosine-protein kinase BMX or Bone marrow tyrosine kinase gene in chromosome X protein) is required for interleukin 6 (IL-6) induced differentiation. BMX may play a role in the growth and differentiation of hematopoietic cells. BMX may be involved in signal transduction in endocardial and arterial endothelial cells. BMX binds 1 zinc ion per subunit and interacts with RUFY1 and RUFY2. BMX is preferentially expressed in epithelial and endothelial cells. BMX is activated by IL-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the PH domain. SH2 domain mediates interaction with RUFY1 and BMX belongs to the protein kinase superfamily, Tyr protein kinase family and TEC subfamily.
Synonyms: ETK (Epithelial and endothelial tyrosine kinase)
|Research Area||Signaling, Tyrosine Kinases|
|Restrictions||For Research Use only|
Tamagnone, Lahtinen, Mustonen et al.: "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2." in: Oncogene, Vol. 9, Issue 12, pp. 3683-8, 1994 (PubMed).
Qiu, Robinson, Pretlow et al.: "Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 7, pp. 3644-9, 1998 (PubMed).
Yang, Kim, Wu et al.: "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking." in: The Journal of biological chemistry, Vol. 277, Issue 33, pp. 30219-26, 2002 (PubMed).
Nore, Mattsson, Antonsson et al.: "Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases." in: Biochimica et biophysica acta, Vol. 1645, Issue 2, pp. 123-32, 2003 (PubMed).
|Hosts||Rabbit (55), Mouse (5)|
|Reactivities||Human (59), Mouse (Murine) (43), Rat (Rattus) (33), Cow (Bovine) (28), Dog (Canine) (28), Horse (Equine) (28), Pig (Porcine) (28), Rabbit (1)|
|Applications||Immunofluorescence (IF) (35), Western Blotting (WB) (34), ELISA (22), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (12), Immunohistochemistry (IHC) (10), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunocytochemistry (ICC) (2), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), PE,Cy5.5 (3), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)|
|Epitopes||pTyr40 (6), pTyr556 (4), N-Term (2), C-Term (1), Center (1), Cytoplasmic,C-Term (1), Internal Region (1), pSer106,pSer104 (1), pSer1423 (1), pTyr566 (1)|