anti-BRCA1 antibody (Breast Cancer 1) (pSer1423)

Details for Product anti-BRCA1 Antibody No. ABIN965694
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Antigen
Synonyms BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
Epitope
pSer1423
(43), (38), (24), (24), (23), (23), (19), (17), (14), (14), (14), (14), (12), (12), (8), (7), (7), (7), (5), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(453), (33), (21), (1), (1), (1), (1), (1)
Host
Rabbit
(383), (70), (5), (3)
Conjugate
This BRCA1 antibody is un-conjugated
(18), (16), (13), (8), (8), (8), (8), (8), (8), (8), (8), (3), (3), (3), (2), (2), (2), (1)
Application
Immunohistochemistry (IHC)
(285), (126), (118), (92), (81), (79), (70), (15), (12), (3), (3), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 100 μg
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human BRCA1 around the phosphorylation site of serine 1423 (H-G-SP-Q-P).
Specificity BRCA1 (phospho-Ser1423) antibody detects endogenous levels of BRCA1 only when phosphorylated at serine 1423.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name BRCA1 (BRCA1 Antibody Abstract)
Research Area Cancer, Transcription Factors, Proteolysis / Ubiquitin, DNA/RNA
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Greenberg, Sobhian, Pathania et al.: "Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes." in: Genes & development, Vol. 20, Issue 1, pp. 34-46, 2006 (PubMed).

Arlt, Xu, Durkin et al.: "BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function." in: Molecular and cellular biology, Vol. 24, Issue 15, pp. 6701-9, 2004 (PubMed).

Zhang, Willers, Feng et al.: "Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 708-18, 2003 (PubMed).

Kim, Xu, Kastan: "Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage." in: Genes & development, Vol. 16, Issue 5, pp. 560-70, 2002 (PubMed).

Tibbetts, Cortez, Brumbaugh et al.: "Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress." in: Genes & development, Vol. 14, Issue 23, pp. 2989-3002, 2000 (PubMed).

Validation Images
Catalog No. ABIN965694
398.75 $
Plus shipping costs $45.00
Quantity
Price
100 μg
398.75 $

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