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Breast Cancer 1, Early Onset (BRCA1) (pSer1423) antibody

Antigen

Breast Cancer 1, Early Onset (BRCA1)
Synonyms BRCA1, iris, pscp, brcai, brcc1, rnf53, brca1, LOC100224649, IRIS, PSCP, BRCAI, BRCC1, RNF53, BROVCA1, ARABIDOPSIS THALIANA BREAST CANCER SUSCEPTIBILITY1, ATBRCA1, breast cancer susceptibility1
Binding Site
Alternatives

pSer1423
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC)
5 references available
Catalog no. ABIN965694
Quantity 100ug  (100ug/100ul.)  (Variants)
Price 385.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name BRCA1
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human BRCA1 around the phosphorylation site of serine 1423 (H-G-SP-Q-P).
Specificity BRCA1 (phospho-Ser1423) antibody detects endogenous levels of BRCA1 only when phosphorylated at serine 1423.

Application Details
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Application Notes IHC: 1:50-1:100.
Concentration 100ug/100ul.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative 0.02% Sodium Azide
Storage Store at -20°C/1 year.
Research Area Cancer, Transcription Factors, Proteolysis / Ubiquitin, DNA/RNA
Restrictions For Research Use only

Publications
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Product Tibbetts, Cortez, Brumbaugh et al.: "Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress." in: Genes & development, Vol. 14, Issue 23, pp. 2989-3002, 2000 (PubMed).

Kim, Xu, Kastan: "Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage." in: Genes & development, Vol. 16, Issue 5, pp. 560-70, 2002 (PubMed).

Zhang, Willers, Feng et al.: "Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 708-18, 2003 (PubMed).

Arlt, Xu, Durkin et al.: "BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function." in: Molecular and cellular biology, Vol. 24, Issue 15, pp. 6701-9, 2004 (PubMed).

Greenberg, Sobhian, Pathania et al.: "Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes." in: Genes & development, Vol. 20, Issue 1, pp. 34-46, 2006 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Breast Cancer 1, Early Onset (BRCA1)", type "Antibodies"
Hosts Rabbit (134), Mouse (22), Chicken (2)
Reactivities Human (154), Rat (Rattus) (12), Mouse (Murine) (9), Cat (Feline) (1), Chicken (1), Cow (Bovine) (1), Dog (Canine) (1)
Applications Western Blotting (WB) (79), Immunofluorescence (IF) (47), Immunohistochemistry (IHC) (43), ELISA (32), Immunoprecipitation (IP) (32), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (28), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Flow Cytometry (FACS) (1), Functional Studies (Func) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (4), Alexa Fluor 488 (4), Alexa Fluor 555 (4), Alexa Fluor 647 (4), Biotin (3), PE,Cy5.5 (3), FITC (2), HRP (2), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes pSer1423 (19), pSer1524 (18), Ser988 (12), pSer988 (10), pSer1189 (8), C-Term (6), N-Term (5), AA 341-748 (4), AA 1314-1864 (3), AA 762-1315 (3), Ser1423 (3), Ser1524 (2), pSer1457 (2), AA 1301-1863 (1), AA 1395-1454 (1), AA 1800-1863 (1), AA 1847-1863 (1), AA 1848-1863 (1), AA 341-784 (1), Internal Region (1), Phosphospecific (1), pSer1280 (1), pSer1387 (1), pSer1466 (1), pSer1497 (1), pSer365 (1), pThr129 (1), phospho (1)