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BRCA1 antibody (Breast Cancer 1) (pSer1524)

Details for Product anti-BRCA1 Antibody No. ABIN965695, Supplier: Log in to see
Antigen
  • BRCAI
  • BRCC1
  • BROVCA1
  • IRIS
  • PNCA4
  • PPP1R53
  • PSCP
  • RNF53
  • breast cancer 1
  • breast cancer 1, early onset
  • Brca1
  • BRCA1
Alternatives
anti-Human BRCA1 antibody for Immunohistochemistry (Frozen Sections)
Epitope
pSer1524
78
34
29
28
24
22
18
18
18
18
15
15
10
10
9
8
8
7
5
5
5
5
5
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
561
55
46
10
1
1
Host
Rabbit
388
179
4
3
Conjugate
This BRCA1 antibody is un-conjugated
23
19
19
11
11
8
8
7
6
6
6
6
6
6
6
6
6
6
5
5
5
5
5
5
5
5
3
2
2
2
Application
Immunohistochemistry (IHC)
337
153
122
114
99
98
95
81
78
6
5
5
4
4
2
2
1
1
Options
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human BRCA1 around the phosphorylation site of serine 1524 (Y-P-SP-Q-E).
Specificity BRCA1 (phospho-Ser1524) antibody detects endogenous levels of BRCA1 only when phosphorylated at serine 1524.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name BRCA1 (BRCA1 Antibody Abstract)
Research Area Cancer, Transcription Factors, Proteolysis / Ubiquitin, DNA/RNA
Pathways Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Lin, Li, Stewart, Elledge: "Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 17, pp. 6484-9, 2004 (PubMed).

Zheng, Annab, Afshari, Lee, Boyer: "BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 17, pp. 9587-92, 2001 (PubMed).

Beger, Pierce, Kruger, Marcusson, Robbins, Welcsh, Welch, Welte, King, Barber, Wong-Staal: "Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 1, pp. 130-5, 2001 (PubMed).

Gardner, Liu: "BRCA1 function in T lymphocytes: a cellular specificity of a different kind." in: Breast cancer research : BCR, Vol. 3, Issue 1, pp. 11-3, 2001 (PubMed).

Product cited in: Zhang, Willers, Feng, Ghosh, Kim, Weaver, Chung, Powell, Xia: "Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 708-18, 2003 (PubMed).