Breast Cancer 1 (BRCA1) (pSer1524) antibody

Details for Product No. ABIN965695
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Antigen
Synonyms BRCA1
Epitope
pSer1524
(42), (35), (24), (20), (17), (17), (15), (15), (15), (14), (12), (9), (7), (7), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(361), (44), (25), (13), (2), (1), (1), (1)
Host
Rabbit
(321), (61), (3), (1)
Conjugate
Un-conjugated
(16), (15), (13), (9), (9), (9), (9), (9), (9), (9), (9), (3), (3), (3), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(216), (105), (90), (86), (73), (72), (55), (6), (5), (3), (1), (1)
Pubmed 5 references available
Catalog no. ABIN965695
Quantity 100 µg
Price
385.00 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 5 to 7 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human BRCA1 around the phosphorylation site of serine 1524 (Y-P-SP-Q-E).
Specificity BRCA1 (phospho-Ser1524) antibody detects endogenous levels of BRCA1 only when phosphorylated at serine 1524.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name BRCA1
Research Area Cancer, Transcription Factors, Proteolysis / Ubiquitin, DNA/RNA
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Beger, Pierce, Kruger et al.: "Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 1, pp. 130-5, 2001 (PubMed).

Gardner, Liu: "BRCA1 function in T lymphocytes: a cellular specificity of a different kind." in: Breast cancer research : BCR, Vol. 3, Issue 1, pp. 11-3, 2001 (PubMed).

Zheng, Annab, Afshari et al.: "BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 17, pp. 9587-92, 2001 (PubMed).

Zhang, Willers, Feng et al.: "Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 708-18, 2003 (PubMed).

Lin, Li, Stewart et al.: "Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 17, pp. 6484-9, 2004 (PubMed).

Hosts (321), (61), (3), (1)
Reactivities (361), (44), (25), (13), (2), (1), (1), (1)
Applications (216), (105), (90), (86), (73), (72), (55), (6), (5), (3), (1), (1)
Conjugates (16), (15), (13), (9), (9), (9), (9), (9), (9), (9), (9), (3), (3), (3), (1), (1), (1)
Epitopes (42), (35), (24), (20), (17), (17), (15), (15), (15), (14), (12), (9), (7), (7), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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