BRCA1 antibody (Breast Cancer 1)

Details for Product anti-BRCA1 Antibody No. ABIN965696, Supplier: Log in to see
Antigen
  • BRCAI
  • BRCC1
  • BROVCA1
  • IRIS
  • PNCA4
  • PPP1R53
  • PSCP
  • RNF53
  • iris
  • pscp
  • brcai
  • brcc1
  • rnf53
  • brca1
  • BRCA1
  • LOC100224649
  • breast cancer 1, early onset
  • breast cancer 1
  • BRCA1
  • brca1
  • LOC100224649
  • LOC100347269
  • Brca1
Alternatives
anti-Human BRCA1 antibody for Immunohistochemistry (Frozen Sections)
Reactivity
Human
623
75
58
10
2
1
1
1
1
Host
Rabbit
394
235
4
3
Clonality
Polyclonal
Conjugate
This BRCA1 antibody is un-conjugated
27
23
23
15
15
12
12
10
9
9
9
9
9
9
7
6
6
6
6
6
6
6
6
6
5
5
3
2
2
2
Application
Immunohistochemistry (IHC)
393
193
167
139
134
113
98
81
78
6
5
5
5
4
2
2
1
1
Options
Supplier
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human BRCA1 around the phosphorylation site of serine 1423 (H-G-SP-Q-P).
Specificity BRCA1 (Ab-1423) antibody detects endogenous levels of total BRCA1 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name BRCA1 (BRCA1 Antibody Abstract)
Pathways Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Greenberg, Sobhian, Pathania, Cantor, Nakatani, Livingston: "Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes." in: Genes & development, Vol. 20, Issue 1, pp. 34-46, 2006 (PubMed).

Arlt, Xu, Durkin, Casper, Kastan, Glover: "BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function." in: Molecular and cellular biology, Vol. 24, Issue 15, pp. 6701-9, 2004 (PubMed).

Zhang, Willers, Feng, Ghosh, Kim, Weaver, Chung, Powell, Xia: "Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 708-18, 2003 (PubMed).

Kim, Xu, Kastan: "Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage." in: Genes & development, Vol. 16, Issue 5, pp. 560-70, 2002 (PubMed).

Tibbetts, Cortez, Brumbaugh, Scully, Livingston, Elledge, Abraham: "Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress." in: Genes & development, Vol. 14, Issue 23, pp. 2989-3002, 2000 (PubMed).

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