Bruton Agammaglobulinemia tyrosine Kinase (BTK) antibody

Details for Product No. ABIN965707
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Antigen
Synonyms BTK, atk, bpk, xla, imd1, agmx1, psctk1, AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA, AI528679, xid
Reactivity
Human
(163), (75), (68), (36), (36), (24), (7), (1)
Host
(127), (36)
Clonality
Monoclonal
Conjugate
Un-conjugated
(7), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
(126), (62), (45), (40), (35), (33), (17), (17), (2), (1)
Pubmed 3 references available
Quantity 0.1 mL
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN965707
426.25 $
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Isotype IgG1
Specificity Ni-NTA purified truncated recombinant BTK expressed in E. Coli strain BL21 (DE3)
Purification Crude ascites.
Alternative Name BTK
Background Brutons tyrosine kinase (BTK) is a member of the BTK/ Tec family of cytoplasmic tyrosine kinases.All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini.BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.
Gene ID 695
Research Area Immunology, Innate Immunity, Tyrosine Kinases
Application Notes Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Product cited in: Tamagnone, Lahtinen, Mustonen et al.: "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2." in: Oncogene, Vol. 9, Issue 12, pp. 3683-8, 1994 (PubMed).

Thomas, Sideras, Smith et al.: "Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes." in: Science (New York, N.Y.), Vol. 261, Issue 5119, pp. 355-8, 1993 (PubMed).

Yamada, Kawakami, Kimura et al.: "Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells." in: Biochemical and biophysical research communications, Vol. 192, Issue 1, pp. 231-40, 1993 (PubMed).

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