C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr412) antibody

Details for Product No. ABIN965708
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Antigen
Synonyms ABL1, ABL, CABL, ABLL, cb272, JTK7, bcr/abl, c-ABL, p150, v-abl, AI325092, Abl, E430008G22Rik, c-Abl, MTP
Epitope
pTyr412
(48), (35), (31), (26), (25), (17), (16), (14), (13), (13), (13), (12), (12), (12), (12), (12), (12), (12), (12), (11), (9), (7), (7), (6), (6), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(506), (341), (289), (204), (193), (180), (60), (48), (4), (1), (1)
Host
Rabbit
(500), (20)
Conjugate
Un-conjugated
(26), (23), (23), (19), (19), (19), (19), (19), (19), (19), (19), (8), (8), (8)
Application
Immunohistochemistry (IHC)
(292), (190), (153), (114), (113), (48), (23), (20), (14), (11), (3), (2)
Pubmed 4 references available
Quantity 100 µg
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Catalog No. ABIN965708
385.00 $
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human cAbl around the phosphorylation site of tyrosine 412 (D-T-YP-T-A).
Specificity C-Abl (phospho-Tyr412) antibody detects endogenous levels of c-Abl only when phosphorylated at tyrosine 412.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name c-Abl
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Kharbanda, Pandey, Yamauchi et al.: "Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 4979-89, 2000 (PubMed).

Sionov, Coen, Goldberg et al.: "c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination." in: Molecular and cellular biology, Vol. 21, Issue 17, pp. 5869-78, 2001 (PubMed).

Yoshida, Komatsu, Wang et al.: "c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3292-300, 2002 (PubMed).

Kawai, Nie, Yuan: "Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl." in: Molecular and cellular biology, Vol. 22, Issue 17, pp. 6079-88, 2002 (PubMed).

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