ABL1 antibody (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase) (pTyr412)

Details for Product anti-ABL1 Antibody No. ABIN965708, Supplier: Log in to see
Antigen
  • ABL1
  • ABL
  • CABL
  • ABLL
  • cb272
  • JTK7
  • bcr/abl
  • c-ABL
  • p150
  • v-abl
  • AI325092
  • Abl
  • E430008G22Rik
  • c-Abl
  • MTP
  • c-abl oncogene 1, receptor tyrosine kinase
  • c-abl oncogene 1, non-receptor tyrosine kinase
  • v-abl Abelson murine leukemia viral oncogene homolog 2
  • microsomal triglyceride transfer protein
  • Protein ABL-1
  • ABL1
  • ABL2
  • abl2
  • Abl1
  • MTTP
  • abl-1
Alternatives
anti-Human ABL1 antibody for Immunofluorescence
Epitope
pTyr412
57
55
44
35
31
29
25
17
16
16
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15
15
15
15
15
15
12
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11
8
7
7
6
6
6
6
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
623
403
317
10
4
3
1
1
1
1
Host
Rabbit
622
22
Conjugate
This ABL1 antibody is un-conjugated
32
31
29
16
16
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15
15
15
1
Application
Immunohistochemistry (IHC)
367
195
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169
121
69
44
24
16
11
6
2
2
1
Options
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human cAbl around the phosphorylation site of tyrosine 412 (D-T-YP-T-A).
Specificity C-Abl (phospho-Tyr412) antibody detects endogenous levels of c-Abl only when phosphorylated at tyrosine 412.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name C-Abl (ABL1 Antibody Abstract)
Pathways Apoptosis, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Kawai, Nie, Yuan: "Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl." in: Molecular and cellular biology, Vol. 22, Issue 17, pp. 6079-88, 2002 (PubMed).

Yoshida, Komatsu, Wang, Kufe: "c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3292-300, 2002 (PubMed).

Kharbanda, Pandey, Yamauchi, Kumar, Kaneki, Kumar, Bharti, Yuan, Ghanem, Rana, Weichselbaum, Johnson, Kufe: "Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 4979-89, 2000 (PubMed).

Background publications Sionov, Coen, Goldberg, Berger, Bercovich, Ben-Neriah, Ciechanover, Haupt: "c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination." in: Molecular and cellular biology, Vol. 21, Issue 17, pp. 5869-78, 2001 (PubMed).

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