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Tyrosine-protein kinase ABL1 (ABL1) (pTyr412) antibody

Details for Product No. ABIN965708, Supplier: Log in to see
Antigen
Epitope
pTyr412
51
50
38
30
30
26
25
22
17
14
14
14
13
13
13
13
13
13
13
13
12
9
9
8
8
7
7
7
4
4
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
574
324
256
9
3
1
Host
Rabbit
572
22
Conjugate
Un-conjugated
32
31
30
16
16
16
15
15
15
15
15
15
15
15
15
1
Application
Immunohistochemistry (IHC)
344
189
169
165
93
62
45
20
20
6
2
2
1
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human cAbl around the phosphorylation site of tyrosine 412 (D-T-YP-T-A).
Specificity C-Abl (phospho-Tyr412) antibody detects endogenous levels of c-Abl only when phosphorylated at tyrosine 412.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name C-Abl
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Kawai, Nie, Yuan: "Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl." in: Molecular and cellular biology, Vol. 22, Issue 17, pp. 6079-88, 2002 (PubMed).

Yoshida, Komatsu, Wang, Kufe: "c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3292-300, 2002 (PubMed).

Kharbanda, Pandey, Yamauchi, Kumar, Kaneki, Kumar, Bharti, Yuan, Ghanem, Rana, Weichselbaum, Johnson, Kufe: "Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 4979-89, 2000 (PubMed).

Background publications Sionov, Coen, Goldberg, Berger, Bercovich, Ben-Neriah, Ciechanover, Haupt: "c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination." in: Molecular and cellular biology, Vol. 21, Issue 17, pp. 5869-78, 2001 (PubMed).