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C-ErbB-2 Oncoprotein antibody

Details for Product No. ABIN965710, Supplier: Log in to see
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Immunogen Synthetic human c-erbB-2 oncoprotein from intracytoplasmatic part of the c-erbB-2 oncoprotein.
Specificity This antibody is specific against human c-erbB-2 oncoprotein.
Purification Prediluted.
Background Purified immunoglobulin fraction of rabbit antiserum prediluted in Primary Antibody diluting Buffer pH 7.6.
Research Area Cancer
Application Notes This antibody is prediluted for Immunohistochemistry use.
Staining Procedure: The prediluted antibody can be used on frozen cryostat sections as well as formalin-fixed paraffin-embedded tissue sections. For paraffinembedded tissue sections, we recommend an incubation time and temperature of 30 minutes at 37°C for this antibody, when used in conjunction with an immunoperoxidase staining kit. Prolonged fixation in buffered formalin can destroy the epitope.

Recommended Positive Control: Breast AdenoCarcinomas, Ovary, Gastrointestinal Tract

Restrictions For Research Use only
Format Liquid
Concentration 0.007 mg/ml.
Storage 4 °C
Background publications Slamon, Clark, Wong et al.: "Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene." in: Science (New York, N.Y.), Vol. 235, Issue 4785, pp. 177-82, 1987 (PubMed).

Varley, Swallow, Brammar et al.: "Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis." in: Oncogene, Vol. 1, Issue 4, pp. 423-30, 1988 (PubMed).

Bouchard, Lamarre, Tremblay et al.: "Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene." in: Cell, Vol. 57, Issue 6, pp. 931-6, 1989 (PubMed).

Wright, Angus, Nicholson et al.: "Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer." in: Cancer research, Vol. 49, Issue 8, pp. 2087-90, 1989 (PubMed).

Barnes: "Breast cancer and a proto-oncogene." in: BMJ (Clinical research ed.), Vol. 299, Issue 6707, pp. 1061-2, 1990 (PubMed).

May, Mouriesse, May-Levin et al.: "Human breast cancer: identification of populations with a high risk of early relapse in relation to both oestrogen receptor status and c-erbB-2 overexpression." in: British journal of cancer, Vol. 62, Issue 3, pp. 430-5, 1990 (PubMed).

Soomro, Shousha, Taylor et al.: "c-erbB-2 expression in different histological types of invasive breast carcinoma." in: Journal of clinical pathology, Vol. 44, Issue 3, pp. 211-4, 1991 (PubMed).