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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Jun Proto-Oncogene (JUN) (pSer63) antibody
|Synonyms||AP1, AP-1, c-Jun, fj36h07, zgc:65863, wu:fj36h07, jun|
Human, Mouse (Murine)
Alternatives Immunohistochemistry (IHC)
|4 references available|
|Quantity||100ug (100ug/100ul.) (Variants)|
|Price||385.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||The antiserum was produced against synthesized phosphopeptide derived from human c-Jun around the phosphorylation site of serine 63 (L-T-SP-P-D).|
|Specificity||C-Jun (phospho-Ser63) antibody detects endogenous levels of c-Jun only when phosphorylated at serine 63.|
|Purification||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.|
|Buffer||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol|
|Preservative||0.02% Sodium Azide|
|Storage||Store at -20°C/1 year.|
|Research Area||Immunology, Innate Immunity, Transcription Factors|
|Restrictions||For Research Use only|
Hurd, Waldron, Rozengurt: "Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus." in: Oncogene, Vol. 21, Issue 14, pp. 2154-60, 2002 (PubMed).
Li, Feng, Porter: "JNK-dependent phosphorylation of c-Jun on serine 63 mediates nitric oxide-induced apoptosis of neuroblastoma cells." in: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4058-65, 2004 (PubMed).
Sevilla, Santos, Barcia et al.: "c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)." in: Oncogene, Vol. 23, Issue 55, pp. 8950-8, 2004 (PubMed).
Wei, Jin, Schlisio et al.: "The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase." in: Cancer cell, Vol. 8, Issue 1, pp. 25-33, 2005 (PubMed).