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Mast/stem Cell Growth Factor Receptor (KIT) antibody

Details for Product No. ABIN965728, Supplier: Log in to see
Antigen
  • Bs
  • CD117
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • C-Kit
  • PBT
  • SCFR
  • MGF
  • c-kit
Alternatives
anti-Human Mast/stem Cell Growth Factor Receptor antibody for Immunofluorescence
Reactivity
Human
786
384
128
20
16
14
14
11
2
1
Host
619
218
204
4
1
1
Clonality
Monoclonal
Conjugate
Un-conjugated
105
88
81
69
48
40
15
14
11
11
11
8
8
8
8
8
7
6
5
5
4
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
ELISA
362
336
335
174
129
104
92
58
38
30
19
12
11
11
8
4
4
3
2
2
2
2
2
1
Supplier
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Isotype IgG1
Specificity Ni-NTA purified truncated recombinant C-kit expressed in E. Coli strain BL21 (DE3)
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name C-Kit (KIT Antibody Abstract)
Background C-kit (CD117,145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene ckit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.
Gene ID 3815
Research Area Proliferation Markers
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Dilution ELISA: Propose dilution 1: 10,000
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Product cited in: Mojica, Saxena, Starostik et al.: "CD117+ small cell lung cancer lacks the asp 816-->val point mutation in exon 17." in: Histopathology, Vol. 47, Issue 5, pp. 517-22, 2005 (PubMed).

Nakai, Nonomura, Oka et al.: "KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors." in: Biochemical and biophysical research communications, Vol. 337, Issue 1, pp. 289-96, 2005 (PubMed).

Tong, Liu, Zhang et al.: "Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation." in: International journal of colorectal disease, Vol. 20, Issue 4, pp. 363-7, 2005 (PubMed).