Mast/stem Cell Growth Factor Receptor (KIT) antibody

Details for Product No. ABIN965728
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Antigen
Synonyms Bs, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W, c-KIT, C-Kit, PBT, SCFR, MGF, c-kit
Reactivity
Human
(719), (375), (139), (19), (10), (6), (6), (3), (3)
Host
(594), (199), (162), (3), (2), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(101), (83), (79), (66), (50), (41), (20), (13), (11), (9), (9), (9), (9), (9), (6), (6), (4), (4), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
ELISA
(346), (339), (302), (140), (133), (110), (90), (38), (37), (31), (14), (12), (10), (9), (9), (5), (3), (2), (2)
Pubmed 3 references available
Quantity 0.1 mL
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Isotype IgG1
Specificity Ni-NTA purified truncated recombinant C-kit expressed in E. Coli strain BL21 (DE3)
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name C-Kit (KIT Antibody Abstract)
Background C-kit (CD117,145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene ckit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.
Gene ID 3815
Research Area Proliferation Markers
Application Notes Dilution ELISA: Propose dilution 1: 10,000
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Product cited in: Mojica, Saxena, Starostik et al.: "CD117+ small cell lung cancer lacks the asp 816-->val point mutation in exon 17." in: Histopathology, Vol. 47, Issue 5, pp. 517-22, 2005 (PubMed).

Nakai, Nonomura, Oka et al.: "KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors." in: Biochemical and biophysical research communications, Vol. 337, Issue 1, pp. 289-96, 2005 (PubMed).

Tong, Liu, Zhang et al.: "Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation." in: International journal of colorectal disease, Vol. 20, Issue 4, pp. 363-7, 2005 (PubMed).

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Catalog No. ABIN965728
440.00 $
Plus shipping costs $45.00
Quantity
Price
0.1 mL
440.00 $

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