KIT antibody (Mast/stem Cell Growth Factor Receptor)

Details for Product anti-KIT Antibody No. ABIN965728, Supplier: Log in to see
Antigen
  • C-Kit
  • CD117
  • PBT
  • SCFR
  • Bs
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • c-kit
  • MGF
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • kit oncogene
  • KIT
  • Kit
Alternatives
anti-Human KIT antibody for Immunofluorescence
Reactivity
Human
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Host
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Clonality
Monoclonal
Conjugate
This KIT antibody is un-conjugated
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Application
ELISA
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Options
Supplier
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Supplier Product No.
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Isotype IgG1
Specificity Ni-NTA purified truncated recombinant C-kit expressed in E. Coli strain BL21 (DE3)
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name C-Kit (KIT Antibody Abstract)
Background C-kit (CD117,145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene ckit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.
Gene ID 3815
Research Area Proliferation Markers
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes Dilution ELISA: Propose dilution 1: 10,000
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Product cited in: Mojica, Saxena, Starostik, Cheney: "CD117+ small cell lung cancer lacks the asp 816-->val point mutation in exon 17." in: Histopathology, Vol. 47, Issue 5, pp. 517-22, 2005 (PubMed).

Tong, Liu, Zhang, Xiong, Liu, Zhang: "Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation." in: International journal of colorectal disease, Vol. 20, Issue 4, pp. 363-7, 2005 (PubMed).

Nakai, Nonomura, Oka, Shiba, Arai, Nakayama, Inoue, Nishimura, Aozasa, Mizutani, Miki, Okuyama: "KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors." in: Biochemical and biophysical research communications, Vol. 337, Issue 1, pp. 289-96, 2005 (PubMed).

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