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Calpain 3 antibody (C-Term)
CAPN3
Reactivity: Human
IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Calpain 3 Antibody
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Target
See all Calpain 3 (CAPN3) Antibodies
Calpain 3 (CAPN3)
Binding Specificity
All epitopes for Calpain 3 antibodies
C-Term
Reactivity
All reactivities for Calpain 3 antibodies
Human
Host
All hosts for Calpain 3 antibodies
Rabbit
Clonality
All clonalities for Calpain 3 antibodies
Polyclonal
Conjugate
All conjugates for Calpain 3 antibodies
This Calpain 3 antibody is un-conjugated
Application
All applications for Calpain 3 antibodies
Immunohistochemistry (IHC)
Purification
Purified by antigen-specific affinity chromatography.
Immunogen
Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human CAPN3(Calpain-3)
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Alternatives
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Application Details
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Application Notes
ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
This antibody is stored in PBS, 50% glycerol
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Target Details for Calpain 3
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Target
Calpain 3 (CAPN3)
Alternative Name
CAPN3 (CAPN3 Products )
Synonyms
capn3 antibody, MGC80925 antibody, zgc:92687 antibody, CAPN3 antibody, AI323605 antibody, Capa-3 antibody, Capa3 antibody, Lp82 antibody, p94 antibody, Lp84 antibody, Lp85 antibody, CANP3 antibody, CANPL3 antibody, LGMD2 antibody, LGMD2A antibody, nCL-1 antibody, SKM-CALP antibody, SKM-CALPOV antibody, nCL1 antibody, calpain 1, (mu/I) large subunit L homeolog antibody, calpain 3a, (p94) antibody, calpain 3 antibody, capn1.L antibody, capn3a antibody, CAPN3 antibody, Capn3 antibody
Background
CAPN3(Calpain-3) is a calcium-regulated non-lysosomal thiol-protease. It has a broad endopeptidase specificity. CAPN3 is activated by micromolar concentrations of calcium and inhibited by calpastatin. It interacts with TTN/titin. Isoform I is skeletal muscle specific. Defects in CAPN3 are the cause of limb-girdle muscular dystrophy type 2A (LGMD2A). LGMD2A is both autosomal dominantly and recessively transmitted. It is characterized by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase. CAPN3 belongs to the peptidase C2 family and contains 1 calpain catalytic domain and 4 EF-hand domains.
Pathways
Regulation of Muscle Cell Differentiation , Skeletal Muscle Fiber Development
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