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Chromobox Homolog 1 (CBX1) antibody

Details for Product No. ABIN965754, Supplier: Log in to see
Antigen
  • Cbx
  • Cbx-rs2
  • E430007M08Rik
  • HP1B
  • Hp1beta
  • M31
  • MOD1
  • CBX
  • HP1-BETA
  • HP1Hs-beta
  • HP1Hsbeta
  • p25beta
  • cbx1
  • wu:fe14b09
  • zgc:55739
Reactivity
Human, Monkey
85
28
19
8
5
4
2
1
1
1
1
1
1
1
Host
Mouse
42
25
20
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
3
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), ELISA, Western Blotting (WB)
80
51
23
13
10
9
7
5
2
1
1
1
1
1
Supplier
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Immunogen Purified recombinant fragment of human CBX1 expressed in E. Coli.
Clone 5A3
Purification Ascitic fluid
Alternative Name CBX1 (CBX1 Antibody Abstract)
Background This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Gene ID 10951
Application Notes Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Stelzl, Worm, Lalowski et al.: "A human protein-protein interaction network: a resource for annotating the proteome. ..." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005 (PubMed).

Hughes-Davies, Huntsman, Ruas et al.: "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. ..." in: Cell, Vol. 115, Issue 5, pp. 523-35, 2003 (PubMed).