MME antibody

Catalog No. ABIN965758

Product Details anti-MME Antibody

Target: MME (Membrane Metallo-Endopeptidase (MME))

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This MME antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Specificity: Ni-NTA purified recombinant human CD-10 expressed in E. Coli strain BL21 (DE3).

Purification: Antibodies are purified by protein G affinity chromatography.

Isotype: IgG2b

Application Details

Application Notes: IHC(P): Dilution 1: 100- 1: 200
IHC(F): Dilution 1: 200- 1: 400
ELISA: Propose dilution 1: 10000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Storage: -20 °C

References for anti-MME antibody (ABIN965758)

Sato, Itoh, Hinoda, Ohe, Nakagawa, Ueda, Yachi, Imai: "Expression of CD10/neutral endopeptidase in normal and malignant tissues of the human stomach and colon." in: Journal of gastroenterology, Vol. 31, Issue 1, pp. 12-7, (1996) (PubMed).

Inukai, Sugita, Iijima, Tezuka, Goi, Kojika, Shiraishi, Kagami, Nakazawa: "Expression of granulocyte colony-stimulating factor receptor on CD10-positive human B-cell precursors." in: British journal of haematology, Vol. 89, Issue 3, pp. 623-6, (1995) (PubMed).

Target Details for MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Alternative Name: CD10 (MME Products)

Synonyms: CALLA antibody, CD10 antibody, NEP antibody, SFE antibody, 6030454K05Rik antibody, C85356 antibody, Nep antibody, neprilysin antibody, membrane metalloendopeptidase antibody, membrane metallo endopeptidase antibody, membrane metallo-endopeptidase antibody, MME antibody, Mme antibody

Target Type: Chemical

Background: CD10 is a 100kDa glycoprotein, also designated Common Acute Lymphocytic Leukemia Antigen (CALLA). It is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML). It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.

Gene ID: 4311

Pathways: RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration