CD4 Molecule (CD4) antibody

Details for Product No. ABIN965795
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Antigen
Synonyms cd4, L3T4, Ly-4, CD4mut, W3/25, p55
Reactivity
Human
(633), (473), (145), (43), (33), (25), (25), (24), (20), (20), (17), (10), (6), (5), (4), (3), (3), (3), (1)
Host
Mouse
(703), (409), (184), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(182), (132), (121), (68), (35), (17), (15), (10), (10), (10), (9), (8), (7), (6), (6), (6), (6), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
(974), (226), (202), (177), (158), (142), (101), (68), (57), (54), (30), (12), (5), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.5 mL
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Catalog No. ABIN965795
206.25 $
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Immunogen Human leucocytes
Clone B486 (EDU-2)
Isotype IgG2a
Specificity This antibody reacts with a 55kD single chain transmembrane glycoprotien, CD4, expressed on T helper lymphocytes, dendritic cells, microglial cells, and cortical thymus cells. Characteristic of CD4 is its four extracellular immunoglobulin-like domains which help it bind to HLA class II molecules when CD4+ T cells interact with antigenpresenting cells or target cells. Another interesting aspect of the CD4 receptor is the fact that it also serves as the primary receptor for the HIV virus. This antibody was clustered at the 2nd International Leucocyte Typing Workshop.
Purification Concentrated.
Alternative Name CD4
Gene ID 920
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Application Notes Immunohistochemistry: 1:50-1:100.(Frozen sections only)
Flow cytometry: 1:150-1:300.
Staining Procedure: This antibody can be used on frozen sections only. The antibody may be used at a dilution of 1:50-1:100 in IHC. The optimal conditions should be determined by the individual laboratory.
Comment

Recommended Positive Control: Tonsil, Thymus, Spleen

Restrictions For Research Use only
Format Liquid
Concentration 0.3 mg/ml.
Buffer 20 mM tris-borate, 150 mM Sodium Chloride, dialyzed media RPMI 1640/D-MEM containing fetal bovine serum, BMC-6 carrier polysaccharides, carrier protein, pH 7.5
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Reinherz, Kung, Goldstein et al.: "Separation of functional subsets of human T cells by a monoclonal antibody." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 76, Issue 8, pp. 4061-5, 1979 (PubMed).

McDougal, Kennedy, Sligh et al.: "Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule." in: Science (New York, N.Y.), Vol. 231, Issue 4736, pp. 382-5, 1986 (PubMed).

Zosimova: "[Gas chromatographic detection of benzene, toluene and xylene in biological matter]." in: Sudebno-meditsinskaia ekspertiza, Vol. 29, Issue 3, pp. 37-8, 1986 (PubMed).

Dalgleish, Beverley, Clapham et al.: "The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus." in: Nature, Vol. 312, Issue 5996, pp. 763-7, 1985 (PubMed).

Biddison, Rao, Talle et al.: "Possible involvement of the T4 molecule in T cell recognition of class II HLA antigens: evidence from studies of proliferative responses to SB antigens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 131, Issue 1, pp. 152-7, 1983 (PubMed).

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