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CD80 antibody (CD80) (N-Term)

Details for Product anti-CD80 Antibody No. ABIN965820, Supplier: Log in to see
Antigen
  • CD8
  • Leu2
  • MAL
  • p32
  • B71
  • Cd28l
  • Ly-53
  • Ly53
  • MIC17
  • TSA1
  • B7
  • B7-1
  • B7.1
  • BB1
  • CD28LG
  • CD28LG1
  • LAB7
Alternatives
anti-Human CD80 antibody for Immunoprecipitation
Epitope
N-Term, AA 57-71
24
16
15
14
13
13
11
10
9
6
5
5
4
4
3
2
2
2
2
1
1
1
1
1
Reactivity
Human
299
221
49
15
10
9
8
3
2
2
Host
Rabbit
273
109
98
59
16
13
Clonality
Polyclonal
Conjugate
This CD80 antibody is un-conjugated
66
64
41
25
11
10
8
7
5
5
5
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Western Blotting (WB)
359
162
114
101
46
36
24
23
21
18
14
7
7
7
7
5
5
4
3
2
2
2
1
1
1
1
Supplier
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Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human CD80 (57-71aa), identical to the related mouse and rat sequence.
Alternative Name CD80 (CD80 Antibody Abstract)
Background Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. The CD80 genes encode B7-1 which are structurally similar members of the immunoglobulin superfamily expressed on a variety of hematopoietic cell types. Reeves et al. (1997) stated that B7-1 and B7-2 provide a costimulatory signal to T cells by interacting with CD28 and CTLA4.
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB: The detection limit for CD80/ B7-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Stamper, Zhang, Tobin et al.: "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses." in: Nature, Vol. 410, Issue 6828, pp. 608-11, 2001 (PubMed).

Peach, Bajorath, Naemura et al.: "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28." in: The Journal of biological chemistry, Vol. 270, Issue 36, pp. 21181-7, 1995 (PubMed).