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FAS antibody (Fas (TNF Receptor Superfamily, Member 6))

Details for Product anti-FAS Antibody No. ABIN965824, Supplier: Log in to see
Antigen
  • AI196731
  • APO1
  • APT1
  • CD95
  • TNFR6
  • Tnfrsf6
  • lpr
  • TNFRSF6
  • ALPS1A
  • APO-1
  • FAS1
  • FASTM
  • A630082H08Rik
  • FAS
  • Fas (TNF receptor superfamily member 6)
  • Fas (TNF receptor superfamily, member 6)
  • Fas cell surface death receptor
  • fatty acid synthase
  • Fas
  • FAS
  • Fasn
Alternatives
anti-Human FAS antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
664
108
97
15
10
6
4
3
3
3
3
2
1
Host
Mouse
421
301
18
5
4
3
3
Clonality (Clone)
Monoclonal ()
Conjugate
This FAS antibody is un-conjugated
77
64
52
31
16
8
6
6
4
4
4
4
4
4
4
4
4
3
2
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC)
331
313
213
146
116
84
60
52
52
46
21
19
12
7
7
5
5
4
4
3
3
3
2
2
2
1
1
1
1
1
Options
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Immunogen Purified recombinant Fas antigen.
Clone B500 (B-R18)
Isotype IgG1
Specificity This antibody reacts with CD95, a 40-45kD cell surface glycoprotein containing 8kD of N-glycosidic-linked polysaccharide and that is expressed by the CD45RAlow and CD45ROhigh subset of memory T cells.
Purification Concentrated.
Alternative Name CD95 (FAS Antibody Abstract)
Gene ID 355
Research Area Immunology, Innate Immunity, Cytokines, CD Antigens, Apoptosis/Necrosis, Death Receptors, Cancer, Growth Factors, Surface Receptors of Immune Cells
Pathways p53 Signaling, Apoptosis, TCR Signaling
Application Notes Immunohistochemistry: 1:50-1:100.
Flow cytometry: 1:150-1:300.
Staining Procedure: This antibody can be used on frozen and formalin-fixed paraffin-embedded tissue sections. When using with formalin-fixed paraffin embedded tissue sections. The antibody may be used at a dilution of 1:50-1:100 in IHC. The optimal conditions should be determined by the individual laboratory.
Comment

Recommended Positive Control: Tonsil, Spleen, Thymus.

Restrictions For Research Use only
Format Liquid
Concentration 0.3 mg/ml.
Buffer 20 mM tris-borate, 150 mM Sodium Chloride, dialyzed media RPMI 1640/D-MEM containing fetal bovine serum, BMC-6 carrier polysaccharides, carrier protein, pH 7.5
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Debatin, Goldman, Waldmann, Krammer: "APO-1-induced apoptosis of leukemia cells from patients with adult T-cell leukemia." in: Blood, Vol. 81, Issue 11, pp. 2972-7, 1993 (PubMed).

Möller, Henne, Leithäuser, Eichelmann, Schmidt, Brüderlein, Dhein, Krammer et al.: "Coregulation of the APO-1 antigen with intercellular adhesion molecule-1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal ..." in: Blood, Vol. 81, Issue 8, pp. 2067-75, 1993 (PubMed).

Oehm, Behrmann, Falk, Pawlita, Maier, Klas, Li-Weber, Richards, Dhein, Trauth: "Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen." in: The Journal of biological chemistry, Vol. 267, Issue 15, pp. 10709-15, 1992 (PubMed).

Itoh, Yonehara, Ishii, Yonehara, Mizushima, Sameshima, Hase, Seto, Nagata: "The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis." in: Cell, Vol. 66, Issue 2, pp. 233-43, 1991 (PubMed).

Trauth, Klas, Peters, Matzku, Möller, Falk, Debatin, Krammer: "Monoclonal antibody-mediated tumor regression by induction of apoptosis." in: Science (New York, N.Y.), Vol. 245, Issue 4915, pp. 301-5, 1989 (PubMed).