Cyclin-Dependent Kinase 1 (CDK1) antibody

Details for Product No. ABIN965826
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Antigen
Synonyms
CDC2, CDC28A, P34CDC2, Cdc2, Cdc2a, p34, cdc2, wu:fc30e01, zgc:92032, 5363, CDCDm, CDK1, CDK1/CDC2, CG5363, Cdk-1, Cdk1, Dcdc2, Dm cdc2, DmCdc2, DmCdk1, Dmcdc2, Dmel\\CG5363, cdc, cdc2Dm, cdk1,  ... show more
CDC2, CDC28A, P34CDC2, Cdc2, Cdc2a, p34, cdc2, wu:fc30e01, zgc:92032, 5363, CDCDm, CDK1, CDK1/CDC2, CG5363, Cdk-1, Cdk1, Dcdc2, Dm cdc2, DmCdc2, DmCdk1, Dmcdc2, Dmel\\CG5363, cdc, cdc2Dm, cdk1, dCdk1, group 4, l(2)31Eh, CDC2A, CDC2AAT, CDK2, CDKA1, CDKA;1, CYCLIN-DEPENDENT KINASE A;1, cell division control 2 show less
Reactivity
Human
(406), (245), (235), (44), (37), (28), (26), (26), (16), (7), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(329), (113)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(13), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
(357), (143), (111), (86), (62), (60), (57), (39), (19), (11), (11), (5), (3), (1), (1), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN965826
Quantity 0.1 mL
Price
426.25 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of CDC2 expressed in E. Coli.
Clone 8C5A6
Isotype IgG1
Purification Ascitic fluid
Alternative Name CDC2
Background The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.
Synonyms: CDC2, CDC28A, P34CDC2, MGC111195, DKFZp686L20222, CDK1
Molecular Weight 34kDa
Gene ID 983
Research Area Cell Cycle
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Storage 4 °C
Product cited in: Tang, Wu, Guo et al.: "Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition." in: Molecular biology of the cell, Vol. 19, Issue 8, pp. 3536-43, 2008 (PubMed).

Meyer, Merkel, Brückl et al.: "Cdc2 as prognostic marker in stage UICC II colon carcinomas." in: European journal of cancer (Oxford, England : 1990), Vol. 45, Issue 8, pp. 1466-73, 2009 (PubMed).

Hosts (329), (113)
Reactivities (406), (245), (235), (44), (37), (28), (26), (26), (16), (7), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applications (357), (143), (111), (86), (62), (60), (57), (39), (19), (11), (11), (5), (3), (1), (1), (1), (1), (1)
Conjugates (13), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1)
Epitopes (51), (51), (39), (27), (16), (16), (12), (6), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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