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CDC42 antibody (Cell Division Cycle 42 (GTP Binding Protein, 25kDa)) (AA 121-138)

Details for Product anti-CDC42 Antibody No. ABIN965836, Supplier: Log in to see
Antigen
  • AI747189
  • AU018915
  • CDC42
  • Cdc42
  • cdc42
  • cdc42a
  • Cdc42Dm
  • cdc42hs
  • CDC42Hs
  • CG12530
  • D-Cdc42
  • D-CDC42
  • D-cdc42
  • DCDC42
  • DCdc42
  • Dcdc42
  • Dm Cdc42
  • Dmcdc42
  • DmCDC42
  • Dmel\\CG12530
  • g25k
  • G25K
  • wu:fb07d08
  • wu:fi33d02
  • wu:fj62g06
  • Xcdc42
  • zgc:55427
  • zgc:63918
  • zgc:86687
Alternatives
anti-Human CDC42 antibody for Western Blotting
Epitope
AA 121-138
14
13
13
12
11
6
5
5
4
3
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus), Cow (Bovine)
97
42
42
6
6
4
3
2
1
1
Host
79
10
9
Clonality
Polyclonal
Conjugate
This CDC42 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
78
44
18
17
11
7
4
3
2
1
1
1
Supplier
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Supplier Product No.
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Immunogen A synthetic peptide corresponding to a sequence at the middle region of human CDC42 (121-138aa), identical to the related mouse and rat sequence.
Alternative Name CDC42 (CDC42 Antibody Abstract)
Background Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
Research Area Cancer, Cell Cycle, Kinases/Phosphatases
Pathways MAPK Signaling, Microtubule Dynamics, RTK Signaling, WNT Signaling, TCR Signaling, EGFR Signaling Pathway
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Background publications Shinjo, Koland, Hart, Narasimhan, Johnson, Evans, Cerione: "Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 24, pp. 9853-7, 1991

Munemitsu, Innis, Clark, McCormick, Ullrich, Polakis: "Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42." in: Molecular and cellular biology, Vol. 10, Issue 11, pp. 5977-82, 1990