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CDK9 antibody (Cyclin-Dependent Kinase 9)

Details for Product anti-CDK9 Antibody No. ABIN965845, Supplier: Log in to see
Antigen
  • CDK9
  • CG5179
  • Dmel\\CG5179
  • P-TEF
  • P-TEFb
  • PTefb
  • cdk9
  • c-2k
  • cdc2l4
  • ctk1
  • pitalre
  • tak
  • C-2k
  • CDC2L4
  • CTK1
  • PITALRE
  • TAK
  • wu:fb22e09
  • wu:fc06c02
  • Cyclin-dependent kinase 9
  • cyclin-dependent kinase 9
  • cyclin-dependent kinase 9 (CDC2-related kinase)
  • cyclin-dependent kinase 9-like
  • Cdk9
  • CDK9
  • cdk9
  • cdk9-a
  • LOC100855805
Alternatives
anti-Human CDK9 antibody for Western Blotting
Reactivity
Human
147
83
74
7
6
6
6
2
1
1
1
1
Host
Mouse
118
29
Clonality (Clone)
Monoclonal ()
Conjugate
This CDK9 antibody is un-conjugated
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
114
65
40
26
26
24
14
6
5
4
3
3
2
2
1
1
1
Options
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Immunogen Purified recombinant fragment of human CDK9 expressed in E. Coli.
Clone 1B5A7
Isotype IgG1
Purification Ascitic fluid
Alternative Name CDK9 (CDK9 Antibody Abstract)
Background The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.
Tissue specificity: Ubiquitous.
Synonyms: TAK, C-2k, CTK1, CDC2L4, PITALRE
Molecular Weight 43kDa
Gene ID 1025
Research Area Cell Cycle
Pathways Cell Division Cycle
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Montanuy, Torremocha, Hernández-Munain, Suñé: "Promoter influences transcription elongation: TATA-box element mediates the assembly of processive transcription complexes responsive to cyclin-dependent kinase 9." in: The Journal of biological chemistry, Vol. 283, Issue 12, pp. 7368-78, 2008 (PubMed).

Product cited in: Sabò, Lusic, Cereseto, Giacca: "Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2201-12, 2008 (PubMed).