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CES2 (C-Term) antibody

Details for Product No. ABIN965859, Supplier: Log in to see
Antigen
  • CE-2
  • CES2A1
  • PCE-2
  • iCE
  • Ces2
  • ces2A3
  • EG436059
  • Gm5744
Epitope
C-Term
17
15
12
6
5
5
5
3
3
2
2
2
2
2
1
1
1
1
Reactivity
Human
77
11
4
4
Host
Rabbit
67
14
4
1
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
74
48
39
15
11
10
5
4
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human CES2(Carboxylesterase 2 precursor)
Purification Purified by antigen-specific affinity chromatography.
Background CES2(Carboxylesterase 2)is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. CES2 shows high catalytic efficiency for hydrolysis of 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine. CES2 is preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
Research Area Signaling, Metabolism
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Kim, Nakamura, Saito et al.: "Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2)." in: Drug metabolism and pharmacokinetics, Vol. 18, Issue 5, pp. 327-32, 2004 (PubMed).

Saito, Iida, Sekine et al.: "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population." in: Journal of human genetics, Vol. 48, Issue 5, pp. 249-70, 2003 (PubMed).

Pindel, Kedishvili, Abraham et al.: "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin." in: The Journal of biological chemistry, Vol. 272, Issue 23, pp. 14769-75, 1997 (PubMed).

Schwer, Langmann, Daig et al.: "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver." in: Biochemical and biophysical research communications, Vol. 233, Issue 1, pp. 117-20, 1997 (PubMed).